一、中文名称：Anti-Semaglutide (GLP-1 analogue) Antibody (SAb2275) (RHK13902)小分子抗体，抗司美格鲁肽（胰高血糖素样肽-1类似物）抗体（SAb2275），高品质抗体
二、产品描述
司美格鲁肽（Semaglutide）是人胰高血糖素样肽-1的一个长效类似物，是人胰高血糖素样肽-1 (GLP-1)受体的激动剂。胰高血糖素在葡萄糖代谢和体内平衡中起关键作用，通过增加糖异生和减少糖酵解来调节血糖。胰岛素的一种反调节激素，在胰岛素诱导的低血糖时升高血糖水平。在启动和维持糖尿病患者的高血糖状况中起重要作用。
GLP-1 是一种有效的葡萄糖依赖性胰岛素释放刺激剂。在胃动力和抑制血浆胰高血糖素水平方面发挥重要作用。可能参与外周组织中饱腹感的抑制和葡萄糖释放的刺激，与胰岛素的作用无关。对肠上皮有促进生长的活性。还可以通过影响 LH、TSH、CRH、催产素和加压素分泌来调节下丘脑垂体轴 （HPA）。通过刺激胰岛新生和胰腺 β 细胞增殖来增加胰岛质量。抑制 β 细胞凋亡。司美格鲁肽（Semaglutide）有潜力用于2型糖尿病的研究。
三、产品详情
货号：RHK13902
物种反应性：Human
宿主：Mouse
同种型：IgG2a, kappa
克隆性：Monoclonal
靶标：Semaglutide, GLP-1 analogue
浓度：1 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession：P01275
应用：ELISA
状态：Liquid
储存缓冲液：0.01M PBS, pH 7.4.
稳定性和储存条件：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
克隆ID：SAb2275
四、参考文献：
1、Influence of Dulaglutide on Serum Biomarkers of Atherosclerotic Plaque Instability: An Interventional Analysis of Cytokine Profiles in Diabetic Subjects-A Pilot Study. PMID: 38929525
2、An indirect treatment comparison of the efficacy of semaglutide 1.0 mg versus dulaglutide 3.0 and 4.5 mg. PMID: 34286894
3、Oral semaglutide versus injectable glucagon-like peptide-1 receptor agonists: a cost of control analysis. PMID: 31990244
4、Managing the multifaceted nature of type 2 diabetes using once-weekly injectable GLP-1 receptor agonist therapy. PMID: 32910488
5、Cross-sectional, case-control and longitudinal associations between exposure to glucagon-like peptide-1 receptor agonists and the dispensing of antidepressants. PMID: 38650544
6、Lifetime Cost-effectiveness of Oral Semaglutide Versus Dulaglutide and Liraglutide in Patients With Type 2 Diabetes Inadequately Controlled With Oral Antidiabetics. PMID: 34728099
7、Clinical pharmacology of glucagon-like peptide-1 receptor agonists. PMID: 29949126
8、Glucagon-like peptide-1 receptor agonists in type 2 diabetes treatment: are they all the same? PMID: 30156747
9、Efficacy and safety of glucagon-like peptide-1 receptor agonists in type 2 diabetes: A systematic review and mixed-treatment comparison analysis. PMID: 27981757
10、Improvement of glycaemic control and treatment satisfaction by switching from liraglutide or dulaglutide to subcutaneous semaglutide in patients with type 2 diabetes: A multicentre, prospective, randomized, open-label, parallel-group comparison study (SWITCH-SEMA 1 study). PMID: 36722623
11、Glucagon-Like Peptide-1 Receptor Agonists for Type 2 Diabetes: A Clinical Update of Safety and Efficacy. PMID: 26694823
12、Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7): a randomised, open-label, phase 3b trial. PMID: 29397376
13、Comparative efficacy and tolerability of currently approved incretin mimetics: A systematic analysis of placebo-controlled clinical trials. PMID: 40212008
14、Long-acting GLP-1RAs: An overview of efficacy, safety, and their role in type 2 diabetes management. PMID: 32740121
15、Glucagon-Like Peptide 1 Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors Improve Renal Resistive Index in Patients With Type 2 Diabetes: A 26-Week Prospective Observational Real-Life Study. PMID: 39963363
16、Cost-effectiveness of once-weekly semaglutide versus dulaglutide and lixisenatide in patients with type 2 diabetes with inadequate glycemic control in Sweden. PMID: 31044636
17、Comparing regional brain uptake of incretin receptor agonists after intranasal delivery in CD-1 mice and the APP/PS1 mouse model of Alzheimer's disease. PMID: 39085976
18、Safety of Once-weekly Glucagon-like Peptide-1 Receptor Agonists in Patients with Type 2 Diabetes. PMID: 29912998
详情请咨询Antibodysystem中国授权总代理-武汉佰乐博生物技术有限公司
网址：https://www.antibodysystem.com/product/37509.html
武汉佰乐博生物技术有限公司作为法国Antibodysystem品牌亚洲区授权总代理。提供近3万种蛋白、抗体等核心生命科学试剂，旨在为生命科学科研工作者提供专业、全面、可靠的试剂产品。
试剂 | 耗材 | 定制 | 实验服务 | 供应链
免费热线：027-65279366 /18108604356
