一、中文名称：
Recombinant HPV18 E6/Protein E6 Protein, N-His，重组HPV18 E6蛋白，N-His，精品重组蛋白
二、产品描述
HPV18 E6蛋白通过靶向宿主p53蛋白并介导其泛素化降解，破坏细胞周期调控及DNA损伤修复，同时激活端粒酶（hTERT）以维持端粒长度、诱导细胞永生化，并干扰干扰素信号及抗原呈递相关分子（如IRF3、MHC-I），促进免疫逃逸和病毒持续感染。其功能特性（如与E6AP、p53的互作）可通过Co-IP或细胞永生化模型验证，广泛应用于HPV18致癌机制解析、治疗性疫苗开发（如T细胞免疫原）、诊断标志物筛选（ELISA检测E6抗体）及小分子抑制剂的高通量药物筛选。
三、产品详情
名称：Recombinant HPV18 E6/Protein E6 Protein, N-His，重组HPV18 E6蛋白，N-His，精品重组蛋白，活性蛋白，重组蛋白
货号: YVV09002
表达系统: E. coli
种属: Human papillomavirus type 18
蛋白长度: Met1-Val158
预测分子量: 21.02 kDa
性质: Recombinant
内毒素水平: Please contact with the lab for this information.
纯度: >90% as determined by SDS-PAGE.
Accession号: P06463
应用: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
状态: Lyophilized
保存溶液: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
重悬: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名: Protein E6, E6
四、参考文献：
Mitotic control of human papillomavirus genome-containing cells is regulated by the function of the PDZ-binding motif of the E6 oncoprotein. PMID: 28061478
Human papilloma virus (HPV) 18 proteins E6 and E7 up-regulate ABC transporters in oropharyngeal carcinoma. Involvement of the nonsense-mediated decay (NMD) pathway. PMID: 29715486
Reciprocal transactivation of Merkel cell polyomavirus and high-risk human papillomavirus promoter activities and increased expression of their oncoproteins. PMID: 34217322
Reduced MAGI3 level by HPV18E6 contributes to Wnt/β-catenin signaling activation and cervical cancer progression. PMID: 34510826
Novel competitive enzyme-linked immunosorbent assay for the detection of the high-risk Human Papillomavirus 18 E6 oncoprotein. PMID: 37582106
Regulation of human papillomavirus E6 oncoprotein function via a novel ubiquitin ligase FBXO4. PMID: 39688415
详情请咨询Antibodysystem中国授权总代理-武汉佰乐博生物技术有限公司
网址：https://www.biolabreagent.com/product/100/21906.html
武汉佰乐博生物技术有限公司作为法国Antibodysystem品牌亚洲区授权总代理。提供近3万种蛋白、抗体等核心生命科学试剂，旨在为生命科学科研工作者提供专业、全面、可靠的试剂产品。
试剂 | 耗材 | 定制 | 实验服务 | 供应链
免费热线：027-65279366 /18108604356
