一、中文名称：Research Grade Ramatercept，研究级Ramatercept类似物
二、产品描述
Ramatercept (ACE-031) 是MSTN 抑制剂(生长分化因子-8 抑制剂)，也是一种可溶的 ActRIIB 受体，能作为可溶性激活素受体 2 (ACVR2) 拮抗剂。Ramatercept 抑制肌生长抑制信号通路，在肌萎缩中有潜在应用。。
三、产品详情
名称：Research Grade Ramatercept (DHA30606)
别名：ACE-031,ActRIIB-IgG1,ActRIIb:Fc Fusion Protein,HGT-4510,RAP-031, CAS: 1169766-01-1
货号：DHA30606
表达系统：Mammalian Cells
种属反应性：Human
同种型：Fusion - [ACVR2B (activin A receptor type 2B, ActR-IIB, ActRIIB)]2 - IGHG1 Fc (Fragment constant)
靶标：GDF-8, GDF8, MSTN, Myostatin, Growth/differentiation factor 8
浓度：1 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession号：O14793
克隆号：Ramatercept
应用：Research Grade Biosimilar
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
四、参考文献：
Viscera Characteristics of MSTN-Edited Heterozygous Pigs.PMID:35299949
MSTN modification in goat mediated by TALENs and performance analysis.PMID:35729101
Association of Myostatin Gene Polymorphisms with Strength and Muscle Mass in Athletes: A Systematic Review and Meta-Analysis of the MSTN rs1805086 Mutation.PMID:36360291
MSTN Regulatory Network in Mongolian Horse Muscle Satellite Cells Revealed with miRNA Interference Technologies.PMID:36292721
Differential Expression of MSTN Isoforms in Muscle between Broiler and Layer Chickens.PMID:35268106
A MSTN(Del73C) mutation with FGF5 knockout sheep by CRISPR/Cas9 promotes skeletal muscle myofiber hyperplasia.PMID:39365728
Germline transmission of MSTN knockout cattle via CRISPR-Cas9.PMID:36037573
Targeting the myostatin signaling pathway to treat muscle loss and metabolic dysfunction.PMID:33938454
Myostatin regulates energy homeostasis through autocrine- and paracrine-mediated microenvironment communication.PMID:38889010
Reproduction and viscera organ characteristics of MSTN and FGF5 dual-gene knockout sheep.PMID:37065235
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