一、中文名称：Research Grade Dalantercept (DHB63201)，研究级Dalantercept类似物
二、产品描述
ALK1 是 TGFβ超家族的 1 型受体，选择性表达于内皮细胞，与其配体 BMP9 和 BMP10 结合，ALK1/BMP9 信号促进血管稳定成熟，这是 VEGF 驱动血管生成增殖的后期事件。Dalantercept 是 ALK1 受体 -Fc 融合蛋白，与 BMP9 和 BMP10 高亲和力，成为配体陷阱，它抑制血管细胞成熟，削弱 VEGF-A 和碱性成纤维细胞生长因子的作用，后二者无论体内还是体外都会刺激血管生成。
三、产品详情
名称：Research Grade Dalantercept (DHB63201)
别名：ACE-041, CAS: 1186210-24-1
货号：DHB63201
表达系统：Mammalian Cells
种属反应性：Human
同种型：Fusion - [ACVRL1 (activin A receptor like type 1, activin receptor-like kinase 1, ACVRLK1, ALK1, ALK-1, serine/threonine-protein kinase receptor R3, SKR3, HHT, HHT2, ORW2)]2 - IGHG1 Fc (Fragment constant)
靶标：BMP-10, Bone morphogenetic protein 10, BMP10, GDF2, BMP-9, Growth/differentiation factor 2, Bone morphogenetic protein 9, GDF-2, BMP9
浓度：1 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession号：O95393 & Q9UK05
克隆号：Dalantercept
应用：Research Grade Biosimilar
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
四、参考文献：
Activin receptor inhibitors--dalantercept.PMID:25708802
A Phase Ib, Open-Label Study of Dalantercept, an Activin Receptor-Like Kinase 1 Ligand Trap, plus Sorafenib in Advanced Hepatocellular Carcinoma.PMID:30352941
A phase 2, randomized trial evaluating the combination of dalantercept plus axitinib in patients with advanced clear cell renal cell carcinoma.PMID:30951193
Phase II evaluation of dalantercept, a soluble recombinant activin receptor-like kinase 1 (ALK1) receptor fusion protein, for the treatment of recurrent or persistent endometrial cancer: an NRG Oncology/Gynecologic Oncology Group Study 0229N.PMID:25888978
Safety, pharmacokinetics, pharmacodynamics, and antitumor activity of dalantercept, an activin receptor-like kinase-1 ligand trap, in patients with advanced cancer.PMID:24173543
Phase II evaluation of dalantercept in the treatment of persistent or recurrent epithelial ovarian cancer: An NRG Oncology/Gynecologic Oncology Group study.PMID:30041929
A phase 2 study of dalantercept, an activin receptor-like kinase-1 ligand trap, in patients with recurrent or metastatic squamous cell carcinoma of the head and neck.PMID:27648727
Inhibition of ALK1 signaling with dalantercept combined with VEGFR TKI leads to tumor stasis in renal cell carcinoma.PMID:27248821
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