一、中文名称：Research Grade Sotatercept (DHC33102)，研究级Sotatercept类似物
二、产品描述
Sotatercept (ACE-011) 是一种可溶性激活素受体 2A (ACVR2A) 型 IgG Fc 融合蛋白。Sotatercept 结合了激活素和生长分化因子，试图恢复生长促进和生长抑制信号通路之间的平衡。Sotatercept 在肺动脉高压、贫血、骨质流失、红细胞生成、多发性骨髓瘤 (MM) 溶骨性病变中有潜在的应用。
三、产品详情
名称：Research Grade Sotatercept (DHC33102)
别名：ACE-011, ACTRIIA-Fc, MK 7962, MK-7962, MK7962, Sotatercept (USAN/INN), SOTATERCEPT-CSRK, WINREVAIR, CAS: 1001080-50-7
货号：DHC33102
表达系统：Mammalian Cells
种属反应性：Human
同种型：Fusion - [ACVR2A (activin A receptor type 2A, ActR-II, ActRIIA)]2 - IGHG1 Fc (Fragment constant)
靶标：EDF, Erythroid differentiation protein, Activin beta-A chain, INHBA, Inhibin beta A chain
浓度：1.05 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession号：P08476
克隆号：Sotatercept
应用：Research Grade Biosimilar
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
四、参考文献：
Phase 3 Trial of Sotatercept for Treatment of Pulmonary Arterial Hypertension.PMID:36877098
Sotatercept for the Treatment of Pulmonary Arterial Hypertension.PMID:33789009
Sotatercept for the treatment of pulmonary arterial hypertension: PULSAR open-label extension.PMID:36041750
Sotatercept: First Approval.PMID:38904927
Navigating the Sotatercept landscape: A meta-analysis of clinical outcomes.PMID:37819149
Pulmonary Hypertension: A Contemporary Review.PMID:37450768
Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension.PMID:35551212
SPECTRA Phase 2b Study: Impact of Sotatercept on Exercise Tolerance and Right Ventricular Function in Pulmonary Arterial Hypertension.PMID:38572639
Effects of sotatercept on haemodynamics and right heart function: analysis of the STELLAR trial.PMID:37696565
Sotatercept for Pulmonary Arterial Hypertension in the Inpatient Setting.PMID:38361351
Sotatercept: New drug on the horizon of pulmonary hypertension.PMID:39571875
Using Sotatercept in the Care of Patients With Pulmonary Arterial Hypertension.PMID:39004216
Comparative Effectiveness of Sotatercept and Approved Add-On Pulmonary Arterial Hypertension Therapies: A Systematic Review and Network Meta-Analysis.PMID:38820258
Treating Pulmonary Arterial Hypertension With Sotatercept: A Meta-Analysis.PMID:38327917
From bench to bedside: The promise of sotatercept in hematologic disorders.PMID:37516019
A Belgian consensus on sotatercept for the treatment of pulmonary arterial hypertension.PMID:39377139
The Impact of Immunogenicity on the Pharmacokinetics, Efficacy, and Safety of Sotatercept in a Phase III Study of Pulmonary Arterial Hypertension.PMID:38012534
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