一、中文名称：Research Grade Abatacept (DHE03429)，研究级Abatacept类似物
二、产品描述
Abatacept (CTLA4lg) 是一种可溶性融合蛋白，由人 CTLA4 的胞外结构域和人 IgG1 Fc 部分的片段 (铰链，CH2 和 3 结构域) 组成。Abatacept 是选择性 T 细胞共刺激调节剂，也是一种用于自身免疫性疾病的蛋白活性分子。
三、产品详情
名称：Research Grade Abatacept (DHE03429)
货号：DHE03429
表达系统：Mammalian Cells
种属反应性：Human
宿主：Human
同种型：IgG1-Fc
克隆类型：Monoclonal
靶标：CD80, BB1, T-lymphocyte activation antigen CD80, CD28LG, B7, CD28LG1, LAB7, Activation B7-1 antigen, CTLA-4 counter-receptor B7.1, BU63, B70, CD28LG2, CTLA-4 counter-receptor B7.2, Activation B7-2 antigen, T-lymphocyte activation antigen CD86, CD86, FUN-1
浓度：2.29 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession号：P33681 &/or P42081
克隆号：Abatacept
应用：Research Grade Biosimilar
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
四、参考文献：
Trial of Upadacitinib or Abatacept in Rheumatoid Arthritis.PMID:33053283
Phase II Trial of Costimulation Blockade With Abatacept for Prevention of Acute GVHD.PMID:33449816
Abatacept for the treatment of rheumatoid arthritis.PMID:30730220
Abatacept in individuals at high risk of rheumatoid arthritis (APIPPRA): a randomised, double-blind, multicentre, parallel, placebo-controlled, phase 2b clinical trial.PMID:38364839
Abatacept for Delay of Type 1 Diabetes Progression in Stage 1 Relatives at Risk: A Randomized, Double-Masked, Controlled Trial.PMID:36920087
Abatacept in early polymyalgia rheumatica (ALORS): a proof-of-concept, randomised, placebo-controlled, parallel-group trial.PMID:38251563
Abatacept: A Review in Rheumatoid Arthritis.PMID:28608166
Reversal of immune-checkpoint inhibitor fulminant myocarditis using personalized-dose-adjusted abatacept and ruxolitinib: proof of concept.PMID:35383117
[Abatacept].PMID:27311187
Abatacept: A Review of the Treatment of Polyarticular-Course Juvenile Idiopathic Arthritis.PMID:33029724
How does abatacept really work in rheumatoid arthritis?PMID:29401118
Abatacept-Induced Disseminated Superficial Porokeratosis.PMID:33337807
Abatacept for acute graft-versus-host disease prophylaxis after unrelated donor hematopoietic cell transplantation.PMID:39028876
详情请咨询Antibodysystem中国授权总代理-武汉佰乐博生物技术有限公司
网址：https://www.antibodysystem.com/product/660.html
武汉佰乐博生物技术有限公司作为法国Antibodysystem品牌亚洲区授权总代理。提供近3万种蛋白、抗体等核心生命科学试剂，旨在为生命科学科研工作者提供专业、全面、可靠的试剂产品。
试剂 | 耗材 | 定制 | 实验服务 | 供应链
免费热线：027-65279366 /18108604356
