一、中文名称：Anti Digoxin Antibody (26G10)(RGK23001)，地高辛单克隆抗体
二、产品描述
Digoxin是 Na+/K+-ATPase 的有效抑制剂。该抗体对地高辛(一种从毛地黄植物中提取的心脏糖苷)具有特异性。地高辛用于治疗心房颤动、心房扑动和心力衰竭等心脏疾病，其作用是抑制Na+/K+ atp酶。然而，该药的治疗指标非常狭窄，并可能引起毒副作用。由26-10制备的Fab片段，可以中和地高辛的活性，在洋地黄过量的情况下可以用作解毒剂。抗地高辛单克隆抗体也可以用来测量药物的血清水平，作为治疗的指导，并且在抗体和抗原相互作用动力学的研究中是有用的。
三、产品详情
名称：Anti-Digoxin Antibody (26G10) (RGK23001)
别名：Digoxin, DGX, CAS: 20830-75-5,digoxinum,12β-hydroxydigitoxin,ChEBI: 4551, 26-10#, 26G10，Digoxin Monoclonal Antibody
货号：RGK23001
宿主：Mouse
同种型：IgG2a, kappa
克隆类型：Monoclonal
靶标：Digoxin, DGX, CAS: 20830-75-5, digoxinum, 12β-hydroxydigitoxin, ChEBI: 4551, 26-10#, 26G10, RGK60501
浓度：3.4 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
克隆号：26G10
应用：CLIA, DB, ELISA, IP, RIA, WB
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
四、参考文献：
Digoxin targets low density lipoprotein receptor-related protein 4 and protects against osteoarthritis. PMID: 34853001
Role of Digoxin in Atrial Fibrillation. PMID: 27067743
Digoxin protects against intervertebral disc degeneration via TNF/NF-kappaB and LRP4 signaling. PMID: 37790932
Digoxin--issues and controversies. PMID: 3510096
Digoxin. PMID: 1120872
Digoxin--a redundant drug in congestive cardiac failure. PMID: 2488085
Digoxin toxicity in the aged. Characterising and avoiding the problem. PMID: 1794026
Digoxin Exhibits Neuroprotective Properties in a Rat Model of Dementia. PMID: 35064518
Digoxin. PMID: 3185769
A baby with digoxin toxicity. PMID: 25944069
A nomogram for digoxin therapy. PMID: 4600984
Clinical pharmacokinetics of digoxin 1980. PMID: 6988136
Digoxin therapy: textbooks, theory and practice. PMID: 22216507
Digoxin bioavailability. PMID: 82124
A perspective on re-evaluating digoxin's role in the current management of patients with chronic systolic heart failure: targeting serum concentration to reduce hospitalization and improve safety profile. PMID: 24574198
Digoxin in the 1980s. PMID: 3309595
Computer-assisted digoxin therapy. PMID: 4763409
Quinidine-digoxin interaction. PMID: 7436201
Clinical pharmacology of digoxin. PMID: 4558886
How to digitalize and to maintain optimal digoxin levels in congestive heart failure. PMID: 2488083
Digoxin: placental transfer, effects on the fetus, and therapeutic use in the newborn. PMID: 1102216
Digoxin in heart failure. PMID: 2569093
Serum digoxin concentrations in atrial fibrillation: a review. PMID: 7049644
Digoxin therapeutics: straightening out the facts. PMID: 1513197
The rational pharmacology of digoxin. PMID: 1389200
Population Pharmacokinetic Studies of Digoxin in Adult Patients: A Systematic Review. PMID: 33616855
Digoxin Use and Subsequent Outcomes Among Patients in a Contemporary Atrial Fibrillation Cohort. PMID: 26112191
Understanding digoxin use in the elderly patient. PMID: 2253445
Pharmacokinetics of digoxin in the rat. PMID: 3407
Is there an expanded role for digoxin in patients with heart failure and sinus rhythm? A protagonist viewpoint. PMID: 9220052
Digoxin metabolism in patients. PMID: 666466
Serum digoxin test in perspective. PMID: 912635
Bioavailability of digoxin. PMID: 4113330
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