Research Grade Sozinibercept
一、中文名称：
Research Grade Sozinibercept，科研级Sozinibercept
二、产品描述
Sozinibercept 在血管生成研究中作用关键。探索肿瘤生长与转移机制时，它能特异性阻断 VEGFC、VEGF - D 与 VEGFR - 3 的结合，抑制肿瘤相关淋巴管生成。在乳腺癌模型中，使用它可降低肿瘤细胞通过淋巴管转移的几率，为肿瘤转移防治策略研究提供依据。在眼科疾病研究方面，针对湿性年龄相关性黄斑变性（wAMD）的研究显示，Sozinibercept 能抑制脉络膜新生血管形成，调节相关信号通路，减少新生血管，为 wAMD 治疗方法探索提供新方向。在伤口愈合研究中，Sozinibercept 参与调节血管新生和重塑。在皮肤创伤模型实验中，使用它可使伤口处血管生成更有序，促进伤口快速愈合，为理解组织修复机制提供思路。
三、产品详情
名称：Research Grade Sozinibercept，科研级Sozinibercept
货号：DHE70402
表达系统：Mammalian Cells
种属反应性：Human
同种型：Vascular Endothelial Growth Factor Receptor 3 fusion protein with IgG1 Fc Fragment.
克隆类型：Monoclonal
靶标：Vascular endothelial growth factor C, VEGFC, Flt4-L, VEGF-C, Vascular endothelial growth factor-related protein, VRP, Flt4 ligand, Vascular endothelial growth factor D, VEGF-D, FIGF, VEGFD, c-Fos-induced growth factor
浓度：1 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession 号：P49767 & O43915
克隆号：Sozinibercept
应用：Research Grade Biosimilar
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
别名：OPT-302, soluble VEGFR-3, sozinibercept, VGX-300
四、参考文献：
Biosimilar Candidate CT-P42 in Diabetic Macular Edema: 24-Week Results from a Randomized, Active-Controlled, Phase III Study.PMID:38942386
Risk Factors for Meeting Criteria for Switching from Bevacizumab to Aflibercept When Treating Eyes with Diabetic Macular Edema and Visual Acuity of < 20/40.PMID:38336282
Efficacy and Safety of Faricimab for Macular Edema due to Retinal Vein Occlusion: 24-Week Results from the BALATON and COMINO Trials.PMID:38280653
Faricimab for neovascular age-related macular degeneration and diabetic macular edema: from preclinical studies to phase 3 outcomes.PMID:38847896
Efficacy of Intravitreal Injections Anti-Vascular Endothelial Growth Factor Treatment for Radiation Retinopathy: A Systematic Review and Meta-analysis.PMID:38458409
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