Research Grade Telitacicept
一、中文名称：Research Grade Telitacicept，科研级Telitacicept
二、产品描述
Research Grade Telitacicept靶标为肿瘤坏死因子配体超家族成员 13B，在 B 细胞的生命活动中扮演关键角色，通过与 B 细胞表面受体结合，精准调控 B 细胞的存活、增殖与分化，是维持体液免疫平衡的核心环节。一旦该靶标表达异常，会引发一系列严重的自身免疫疾病。在系统性红斑狼疮患者体内，BAFF 过度表达，致使 B 细胞过度活化，产生大量自身抗体，攻击自身组织器官，引发多系统损害；类风湿关节炎患者的关节滑膜中，BAFF 水平升高，促使炎症因子释放，加剧关节炎症和骨质破坏。此外，干燥综合征、原发性胆汁性胆管炎等疾病的发病进程也与 BAFF 密切相关。
三、产品详情
名称：Research Grade Telitacicept，科研级Telitacicept
货号: DHJ85304,
表达系统: Mammalian Cells,
种属反应性: Human,
同种型: Fusion - [TNFRSF13B (tumor necrosis factor receptor (TNFR) superfamily member 13B, TACI, transmembrane activator and CAML Interactor)] 2 - IGHG1 Fc (Fragment constant),
靶标: BAFF, ZTNF4, BLYS, Tumor necrosis factor ligand superfamily member 13B, Dendritic cell-derived TNF-like molecule, TALL-1, TNF- and APOL-related leukocyte expressed ligand 1, BLyS, B lymphocyte stimulator, TNFSF13B, CD257, TNFSF20, TALL1, B-cell-activating factor,
浓度: 1 mg/ml,
内毒素水平: Please contact with the lab for this information.,
纯度: >95% as determined by SDS-PAGE,
纯化方式: Protein A/G purified from cell culture supernatant,
Accession 号: Q9Y275,
克隆号: Telitacicept,
应用: Research Grade Biosimilar,
状态: Liquid,
保存溶液: 0.01M PBS, pH 7.4,
稳定性和存储: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term,
别名: RC18, CAS: 2136630-26-5
四、参考文献：
Telitacicept: First Approval.PMID:34463932
Telitacicept for autoimmune nephropathy.PMID:37342346
Telitacicept as a BLyS/APRIL dual inhibitor for autoimmune disease.PMID:34519594
Randomized Phase 2 Trial of Telitacicept in Patients With IgA Nephropathy With Persistent Proteinuria.PMID:36938094
Telitacicept, a novel humanized, recombinant TACI-Fc fusion protein, for the treatment of systemic lupus erythematosus.PMID:35107091
Role of telitacicept in the treatment of IgA nephropathy.PMID:37737205
Telitacicept: A novel horizon in targeting autoimmunity and rheumatic diseases.PMID:39146891
Telitacicept in patients with active systemic lupus erythematosus: results of a phase 2b, randomised, double-blind, placebo-controlled trial.PMID:38129117
Efficacy and safety of telitacicept in patients with systemic lupus erythematosus: a multicentre, retrospective, real-world study.PMID:38007228
Efficacy and safety of telitacicept in primary Sjogren's syndrome: a randomized, double-blind, placebo-controlled, phase 2 trial.PMID:37399108
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