Research Grade Povetacicept
一、中文名称：
Research Grade Povetacicept，科研级Povetacicept
二、产品描述
Povetacicept对 T、B 淋巴细胞及巨噬细胞等免疫细胞有高亲和力。当免疫系统受病原体入侵或自身免疫失衡时，Povetacicept 迅速结合 BAFF 和 APRIL，阻断它们与细胞表面受体的作用，抑制免疫细胞过度活化，防止免疫过激。临床前研究显示，Povetacicept 能调节多种自身免疫和炎症疾病动物模型的异常免疫反应。在系统性红斑狼疮模型中减少自身抗体，缓解器官损伤；在干燥综合征研究中减轻腺体炎症，改善症状；在类风湿关节炎研究里抑制关节损伤，减轻肿痛和骨质侵蚀，对相关疾病研究和新药研发意义重大。
三、产品详情
名称：Research Grade Povetacicept，科研级Povetacicept
货号：DHB34105
表达系统：Mammalian Cells
种属反应性：Human
同种型：Tumor Necrosis Factor Receptor superfamily protein TNFRSF13b fusion with IgG1 Fc Fragment.
克隆类型：Monoclonal
靶标：TNF- and APOL-related leukocyte expressed ligand 2, APRIL, CD256, Tumor necrosis factor ligand superfamily member 13, TNF-related death ligand 1, TALL-2, TNFSF13, ZTNF2, A proliferation-inducing ligand, TALL2, TRDL-1, BAFF, ZTNF4, BLYS, Tumor necrosis factor ligand superfamily member 13B, Dendritic cell-derived TNF-like molecule, TALL-1, TNF- and APOL-related leukocyte expressed ligand 1, BLyS, B lymphocyte stimulator, TNFSF13B, CD257, TNFSF20, TALL1, B-cell-activating factor
浓度：1 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession 号：O75888 & Q9Y275
克隆号：Povetacicept
应用：Research Grade Biosimilar
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1 - 2 weeks). Store at -20°C 12 months. Store at -80°C long term.
别名：ALPN-303, povetacicept
四、参考文献：
Povetacicept, an Enhanced Dual APRIL/BAFF Antagonist That Modulates B Lymphocytes and Pathogenic Autoantibodies for the Treatment of Lupus and Other B Cell-Related Autoimmune Diseases.PMID:36705554
Antibody based therapeutics for autoimmune hemolytic anemia.PMID:37874225
Autoimmune Hemolytic Anemias: Challenges in Diagnosis and Therapy.PMID:39371250
A first-in-human, randomized study of the safety, pharmacokinetics and pharmacodynamics of povetacicept, an enhanced dual BAFF/APRIL antagonist, in healthy adults.PMID:39494621
Anti-B-Cell-Activating Factor (BAFF) Therapy: A Novel Addition to Autoimmune Disease Management and Potential for Immunomodulatory Therapy in Warm Autoimmune Hemolytic Anemia.PMID:39062171
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