Research Grade Mirococept
一、中文名称：
Research Grade Mirococept，科研级Mirococept
二、产品描述
Mirococept在免疫系统相关的多种细胞环境中均能发挥效用，尤其在树突状细胞、B 淋巴细胞等免疫细胞表面有着较高的亲和结合位点。当机体的免疫反应被激活时，Mirococept 能够迅速且特异性地与关键免疫调节因子 CD40 配体（CD40L）紧密结合，进而阻断 CD40L 与细胞表面天然 CD40 受体的相互作用，有效抑制 CD40 介导的免疫激活信号传导通路。在诸多临床前研究和实验中发现，Mirococept 能够显著降低多种自身免疫性疾病动物模型的免疫过激反应指标，例如在系统性红斑狼疮模型中，它可明显减轻蛋白尿、皮肤红斑以及关节炎症等症状；在类风湿性关节炎的研究里，它同样表现出对炎症发作的有效抑制，降低关节的肿胀程度与疼痛敏感性，这充分表明 Mirococept 在免疫相关疾病的发病机制研究以及新型免疫调节药物研发领域具备极高的研究价值 。
三、产品详情
名称：Research Grade Mirococept，科研级Mirococept
货号：DHB89902
表达系统：Mammalian Cells
种属反应性：Human
同种型：Modified fragment of the Complement Receptor 1 (CR1, CD35)
克隆类型：Monoclonal
靶标：C3, ASP, Complement C3, C3adesArg, C3bc, CPAMD1, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
浓度：1 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession 号：P01024
克隆号：Mirococept
应用：Research Grade Biosimilar
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
别名：APT 070, APT 070C, APT-070, APT-070C
四、参考文献：
Ex vivo delivery of Mirococept: A dose-finding study in pig kidney after showing a low dose is insufficient to reduce delayed graft function in human kidney.PMID:33225626
APT070 (Mirococept), a membrane-localised complement inhibitor, inhibits inflammatory responses that follow intestinal ischaemia and reperfusion injury.PMID:15951831
APT070 (mirococept), a membrane-localizing C3 convertase inhibitor, attenuates early human islet allograft damage in vitro and in vivo in a humanized mouse model.PMID:26565566
A double-blind randomised controlled investigation into the efficacy of Mirococept (APT070) for preventing ischaemia reperfusion injury in the kidney allograft (EMPIRIKAL): study protocol for a randomised controlled trial.PMID:28587616
Attenuation of myocardial reperfusion injury in pigs by Mirococept, a membrane-targeted complement inhibitor derived from human CR1.PMID:17825275
Complement-here, there and everywhere, but what about the transplanted organ?PMID:27179705
Complement inhibition abrogates nerve terminal injury in Miller Fisher syndrome.PMID:16049921
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