Research Grade Acazicolcept
一、中文名称：
Research Grade Acazicolcept，科研级Acazicolcept
二、产品描述
三、产品详情
Research Grade Acazicolcept，科研级Acazicolcept
货号：DHC83404
表达系统：Mammalian Cells
种属反应性：Human
同种型：Fusion - [ICOSLG N-terminal fragment (1-122)] 2 - IGHG1 Fc (Fragment constant)
靶标：CD28, TP44, T-cell-specific surface glycoprotein CD28, CD278, ICOS, Inducible T-cell costimulator, Activation-inducible lymphocyte immunomediatory molecule, AILIM
浓度：1 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession 号：P10747 & Q9Y6W8
克隆号：Acazicolcept
应用：Research Grade Biosimilar
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
别名：ALPN-101,ICOSL vIgD-Fc, CAS: 2270247-50-0
四、参考文献：
Acazicolcept (ALPN-101), a dual ICOS/CD28 antagonist, demonstrates efficacy in systemic sclerosis preclinical mouse models.PMID:34986869
Systemic Administration of Acazicolcept, a Dual CD28 and Inducible T cell Costimulator Inhibitor, Ameliorates Experimental Autoimmune Uveitis.PMID:36976157
Non-Redundant Roles of T Cell Costimulation Pathways in Inflammatory Arthritis Revealed by Dual Blockade of ICOS and CD28 with Acazicolcept (ALPN-101).PMID:36862144
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