一、中文名称：
Human IgG1 (L234A/L235A/G237A), kappa Isotype Control Antibody (HyHEL-10) (RHJ92821)，人 IgG1（L234A/L235A/G237A）、κ 同型对照抗体（HyHEL - 10），精品蛋白抗体试剂盒
二、产品描述
人IgG1，又称人免疫球蛋白G1，是人体IgG抗体的一个亚类，由免疫系统在对抗原作出反应时产生。它是血液中含量最为丰富的IgG亚类，在抵御病原体方面发挥着关键作用。IgG1通过与特定抗原结合，并通过吞噬作用和补体激活等多种机制促进这些抗原从体内清除。IgG1还参与其他免疫反应，如抗体依赖的细胞介导的细胞毒性作用以及毒素的中和。人IgG1可用于研究领域，以探究针对病原体的免疫反应，以及开发针对感染性疾病和自身免疫性疾病的诊断测试和治疗干预手段。
三、产品详情
名称：Human IgG1 (L234A/L235A/G237A), kappa Isotype Control Antibody (HyHEL-10) (RHJ92821)，人 IgG1（L234A/L235A/G237A）、κ 同型对照抗体（HyHEL - 10）体内中和抗体，活性抗体
货号：RHJ92821
宿主：Human
同种型：IgG1 (L234A/L235A/G237A), kappa
克隆类型：Monoclonal
靶标：Human IgG1 (L234A/L235A/G237A),kappa
浓度：1 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
克隆号：HyHEL-10
应用：FCM, Isotype Control, In vivo Control
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
四、参考文献：
Association and dissociation kinetics of anti-hen egg lysozyme monoclonal antibodies HyHEL-5 and HyHEL-10.PMID:9545062
Environmental Effects on Salt Bridge Stability in the Protein-Protein Interface: The Case of Hen Egg-White Lysozyme and Its Antibody, HyHEL-10.PMID:33544613
How do two unrelated antibodies, HyHEL-10 and F9.13.7, recognize the same epitope of hen egg-white lysozyme?PMID:12237453
Energetic analysis of an antigen/antibody interface: alanine scanning mutagenesis and double mutant cycles on the HyHEL-10/lysozyme interaction.PMID:10338006
High-resolution mapping of the HyHEL-10 epitope of chicken lysozyme by site-directed mutagenesis.PMID:7683415
Structural consequences of mutations in interfacial Tyr residues of a protein antigen-antibody complex. The case of HyHEL-10-HEL.PMID:17166830
Quantitative evaluation of the chicken lysozyme epitope in the HyHEL-10 Fab complex: free energies and kinetics.PMID:9761468
Contribution of asparagine residues to the stabilization of a proteinaceous antigen-antibody complex, HyHEL-10-hen egg white lysozyme.PMID:20038580
Light chain somatic mutations change thermodynamics of binding and water coordination in the HyHEL-10 family of antibodies.PMID:19781789
The role of hydrogen bonding via interfacial water molecules in antigen-antibody complexation. The HyHEL-10-HEL interaction.PMID:12444085
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