一、中文名称:
Anti-Mouse DLL3 Antibody (SC16.4),抗小鼠 DLL3 抗体(SC16.4),精品蛋白抗体试剂盒
二、产品描述
Anti DLL3 Antibody ,克隆号SC16.4,DLL3是一种高度肿瘤选择性的细胞表面靶点,主要表达于神经或者神经内分泌肿瘤,包括小细胞肺癌(SCLC)、大细胞神经内分泌癌(LCNEC)、胃肠道神经内分泌瘤(GI-NEC)、小细胞膀胱癌(SCBC)、多形性胶质细胞瘤、转移性去势性前列腺癌、肺神经内分泌瘤等,尤其是SCLC,超过80%的SCLC有DLL3的阳性表达,而正常肺癌组织及癌旁组织中不表达
DLL3属于Notch配体的Delta/Serrate/Lag-2(DSL)家族。DLL3蛋白在肿瘤细胞表面表达,但在正常成人组织中不表达。
三、产品详情
名称:Anti-Mouse DLL3 Antibody (SC16.4),抗小鼠 DLL3 抗体(SC16.4)体内中和抗体,活性抗体
货号:FMK06410
种属反应性:Human, Mouse, Rat
宿主:Mouse
同种型:IgG2a, kappa
克隆类型:Monoclonal
偶联物:Unconjugated
靶标:Drosophila Delta homolog 3, Delta3, Delta-like protein 3, DLL3
浓度:2.24 mg/ml
内毒素水平:Please contact with the lab for this information.
纯度:>95% as determined by SDS-PAGE.
纯化方式:Protein A/G purified from cell culture supernatant.
Accession号:O88516
克隆号:SC16.4
应用:ELISA, FCM
状态:Liquid
保存溶液:0.01M PBS, pH 7.4.
稳定性和存储:Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1 - 2 weeks). Store at -20°C 12 months. Store at -80°C long term.
四、参考文献:
DLL3: an emerging target in small cell lung cancer. PMID: 31215500
A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo. PMID: 26311731
DLL3-guided therapies in small-cell lung cancer: from antibody-drug conjugate to precision immunotherapy and radioimmunotherapy. PMID: 38730427
DLL3 Is a Prognostic and Potentially Predictive Biomarker for Immunotherapy Linked to PD/PD-L Axis and NOTCH1 in Pancreatic Cancer. PMID: 37893184
详情请咨询Antibodysystem中国授权总代理-武汉佰乐博生物技术有限公司
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