一、中文名称：
Anti-Mouse CD137/4-1BB/TNFRSF9 Antibody (3H3) (FMG11020)，抗小鼠 Anti-Mouse CD137/4-1BB/TNFRSF9 (3H3)抗体，精品蛋白抗体试剂盒
二、产品描述
Anti-Mouse 4-1BB/CD137 Antibody (3H3)单克隆抗体与小鼠 4-1BB 反应，后者是 TNF 受体超家族成员，也称为 CD137。4-1BB 是一种 39 kDa 的跨膜蛋白，由 T 淋巴细胞、NK 细胞、树突状细胞、粒细胞和肥大细胞表达。结合其配体 4-1BBL 后，4-1BB 通过激活 NF-κB、c-Jun 和 p38 下游通路向 CD4 和 CD8 T 细胞提供共刺激信号。4-1BB 通路的重要性在包括癌症在内的许多疾病中都得到了强调。据报道，激动性抗 4-1BB 抗体可诱导 T 细胞介导的抗肿瘤免疫。3H3 抗体是一种激动性抗体，已被证明可在体内刺激 4-1BB 信号传导。
三、产品详情
名称：Anti-Mouse CD137/4-1BB/TNFRSF9 Antibody (3H3)体内中和抗体，活性抗体
货号：FMG11020
种属反应性：Mouse
宿主：Rat
同种型：IgG2a, kappa
克隆类型：Monoclonal
偶联物：Unconjugated
靶标：Tumor necrosis factor receptor superfamily member 9, 4-1BB ligand receptor, T-cell antigen 4-1BB, CD137, Tnfrsf9, Ila, Ly63
浓度：1 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession号：P20334
克隆号：3H3
应用：ELISA, FCM
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
四、参考文献：
TCR-independent CD137 (4-1BB) signaling promotes CD8(+)-exhausted T cell proliferation and terminal differentiation.PMID:37392737
CD137 (4-1BB) and T-Lymphocyte Exhaustion.PMID:39120463
New emerging targets in cancer immunotherapy: CD137/4-1BB costimulatory axis.PMID:32611557
CD137 (4-1BB) Costimulation Modifies DNA Methylation in CD8(+) T Cell-Relevant Genes.PMID:29133290
CD137 (4-1BB) stimulation leads to metabolic and functional reprogramming of human monocytes/macrophages enhancing their tumoricidal activity.PMID:34021248
Interfacing T-cell effector and regulatory function through CD137 (4-1BB) co-stimulation.PMID:15979409
Blockade of 4-1BB (CD137)/4-1BB ligand interactions increases allograft survival.PMID:15349720
An Update on Anti-CD137 Antibodies in Immunotherapies for Cancer.PMID:31013788
[The immunotherapy potential of agonistic anti-CD137 (4-1BB) monoclonal antibodies for malignancies and chronic viral diseases].PMID:16670731
CD137+ tumor infiltrating lymphocytes predicts ovarian cancer survival.PMID:38290413
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