抗AKT1多克隆抗体 · 兔源 · 抗原亲和纯化
| 序号 | 您的研究方向 / 需求 | 本产品可直接应用 |
|---|---|---|
| 1 | AKT1蛋白表达水平的定量检测 | 已验证ELISA应用，推荐稀释比1:4000-1:8000 |
| 2 | 组织中AKT1的定位与分布分析 | 已验证IHC应用，推荐稀释比1:50-1:100 |
| 3 | 细胞裂解液中AKT1的蛋白免疫印迹检测 | 已验证WB应用，推荐稀释比1:500-1:4000 |
| 4 | PI3K/AKT/mTOR信号通路与肿瘤研究 | AKT1是PI3K/AKT通路核心激酶，适用于肿瘤靶向治疗研究 |
AKT1（蛋白激酶B alpha, PKBα） 是 AGC蛋白激酶家族 的重要成员，是 PI3K/AKT信号通路 的核心效应分子。AKT1在 细胞生长、增殖、存活、代谢和迁移 等过程中发挥关键调控作用，是连接生长因子受体信号与细胞命运决定的重要枢纽。
AKT1的异常激活与多种 恶性肿瘤 密切相关，包括 乳腺癌、肺癌、胃癌和前列腺癌 等。AKT1通过磷酸化下游靶蛋白（如mTOR、GSK3β、FOXO等），促进 肿瘤细胞存活、代谢重编程和血管生成，并参与 化疗耐药和靶向治疗耐药 的发生。AKT1已成为 肿瘤靶向治疗 的重要靶点，多种AKT抑制剂正在临床研发中。
Anti-AKT1 Polyclonal Antibody 是一种兔源多克隆抗体，可识别人、小鼠、大鼠的AKT1蛋白，已广泛应用于ELISA、IHC和WB检测，是肿瘤生物学、信号转导和代谢研究的 高质量工具抗体。
Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with AKT1 antibody (PHD96501) at 1 μg/ml.
1. Vitamin D and Inhibition of Melanogenesis: Examination of Liposomal Vitamin D Nanocarrier Anti-Melanogenesis Activity on B16 F10 Cell Line. PMID: 40390845
2. Oleanolic acid inhibits mesangial cell proliferation and inflammatory response in mesangial proliferative glomerulonephritis through IL-17/ERK/AKT pathway. PMID: 40088868
3. Inhibition of Kinase Activity and In Vitro Downregulation of the Protein Kinases in Lung Cancer and Cervical Cancer Cell Lines and the Identified Known Anticancer Compounds of Ziziphus mucronata. PMID: 39942957
4. Jian Pi Hua Tan Fang Reverses Trastuzumab Resistance of HER2-Positive Gastric Cancer Through PI3K/AKT/mTOR Pathway: Integrating Network Pharmacology, Molecular Docking and Experimental Validation. PMID: 39917999
5. Elucidating the pharmacological foundations and mechanisms of the Sihai Shuyu formula in treating Graves' disease through integrated serum metabolomics and network pharmacology with molecular docking techniques. PMID: 39950029
| Catalog No. | Product Name |
|---|---|
| PHD96501 | Anti-AKT1 Polyclonal Antibody |
