一、中文名称：
Anti-Human SNCAAlpha-synuclein Antibody (D10)蛋白抗体, 抗人α-突触核蛋白抗体，精品蛋白抗体
二、产品描述
Alpha-Synuclein（α-突触核蛋白）是一种在中枢神经系统突触前及核周表达的可溶性磷蛋白，其分子量约为14-19 kDa。主要定位于成熟神经元的突触前末梢，参与调节突触功能和可塑性。它通过与多巴胺转运蛋白（DAT1）结合，调节多巴胺神经传递，从而在维持神经元稳态和突触传递中发挥关键作用。此外，Alpha-Synuclein还参与调节囊泡的启动、融合和扩张过程，影响神经递质的释放。作为神经元蛋白的一种，Alpha-Synuclein在突触活动中发挥着至关重要的作用，并与多种神经退行性疾病，尤其是帕金森病（Parkinson’s Disease, PD）的发病机制和功能障碍密切相关。
三、产品详情
货号：FHE22010
物种反应性：Human
宿主物种：Mouse
抗体亚型：IgG2a, kappa
克隆性：Monoclonal
偶联物：Unconjugated
靶标：Alpha-synuclein, PARK1, Non-A4 component of amyloid precursor, NACP, Non-A beta component of AD amyloid, SNCA
浓度：1 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
登录号：P37840
应用：ELISA, FCM, IF, WB
形态：Liquid
储存缓冲液：0.01M PBS, pH 7.4, 0.09% Sodium azide.
稳定性与储存条件：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID：D10
四、参考文献
1. Recombinant pro-CTSD (cathepsin D) enhances SNCA/alpha-Synuclein degradation in alpha-Synucleinopathy models. PMID: 35287553
2. MANF Inhibits α-Synuclein Accumulation through Activation of Autophagic Pathways. PMID: 35847585
3. Glucocerebrosidase deficits in sporadic Parkinson disease. PMID: 24915553
4. Ultrasound-Assisted CRISPRi-Exosome for Epigenetic Modification of α-Synuclein Gene in a Mouse Model of Parkinson's Disease. PMID: 38437635
5. SNCA variants and alpha-synuclein level in CD45+ blood cells in Parkinson's disease. PMID: 30316070
6. Generation of two human induced pluripotent stem cell lines (iPSCs) with mutations of the alpha-synuclein (SNCA) gene associated with Parkinson's disease; the A53T mutation (LCSBi003) and a triplication of the SNCA gene (LCSBi007). PMID: 34826737
7. The lysosomal membrane protein LAMP2A promotes autophagic flux and prevents SNCA-induced Parkinson disease-like symptoms in the Drosophila brain. PMID: 29989488
8. Targeting autophagy using small-molecule compounds to improve potential therapy of Parkinson's disease. PMID: 34729301
9. PLK2 disrupts autophagic flux to promote SNCA/alpha-synuclein pathology. PMID: 39773002
10. Induced pluripotent stem cell (iPSC)-derived dopaminergic models of Parkinson's disease. PMID: 24256244
11. HIV-1 Vpr protein impairs lysosome clearance causing SNCA/alpha-synuclein accumulation in neurons. PMID: 33890542
12. Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy models. PMID: 35000546
13. Network-based meta-analysis and the candidate gene association studies reveal novel ethnicity-specific variants in MFSD3 and MRPL43 associated with dementia with Lewy bodies. PMID: 35765761
14. GBA deficiency promotes SNCA/alpha-synuclein accumulation through autophagic inhibition by inactivated PPP2A. PMID: 26378614
15. A monolayer hiPSC culture system for autophagy/mitophagy studies in human dopaminergic neurons. PMID: 32286126
16. Amyloid beta,alpha-Synuclein and Amyloid beta-alpha-Synuclein Combination Exert Significant but Different Alterations in Inflammatory Response Profile in Differentiated Human SH-SY5Y Cells. PMID: 38075821
17. The Progress of Induced Pluripotent Stem Cells as Models of Parkinson's Disease. PMID: 26880962
18. Altered Volatile Organic Compound Profile in Transgenic Rats Bearing A53T Mutation of Human alpha-Synuclein: Comparison with Dopaminergic and Serotonergic Denervation. PMID: 29017011
19. Synucleinphagy: a microglial "community cleanup program" for neuroprotection. PMID: 32453651
20. Cellular reprogramming: a new approach to modelling Parkinson's disease. PMID: 22988881
21. Defective quality control mechanisms and accumulation of damaged mitochondria link Gaucher and Parkinson diseases. PMID: 23989665
22. A novel autophagy modulator 6-Bio ameliorates SNCA/alpha-synuclein toxicity. PMID: 28350199
23. Anti-aging treatments slow propagation of synucleinopathy by restoring lysosomal function. PMID: 27485532
24. Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin. PMID: 27534820
25. Mutant alpha-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation. PMID: 38444039
26. TFEB: Pathogenic role and therapeutic target in Parkinson disease. PMID: 23715007
27. HMGB1 is involved in autophagy inhibition caused by SNCA/alpha-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B. PMID: 24178442
28. R406 and its structural analogs reduce SNCA/alpha-synuclein levels via autophagic degradation. PMID: 40143425
29. G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome. PMID: 23526723
30. Autophagy modulates SNCA/alpha-synuclein release, thereby generating a hostile microenvironment. PMID: 25484190
31. Urate promotes SNCA/alpha-synuclein clearance via regulating mTOR-dependent macroautophagy. PMID: 28821398
32. SNCA (alpha-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy. PMID: 22914317
33. Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/alpha-synuclein aggregation. PMID: 26292069
34. Human amyloid beta and alpha-synuclein co-expression in neurons impair behavior and recapitulate features for Lewy body dementia in Caenorhabditis elegans. PMID: 34146705
35. Inhibition of autophagic flux by S-nitrosylation of SQSTM1/p62 promotes neuronal secretion and cell-to-cell transmission of SNCA/alpha-synuclein in Parkinson disease and Lewy body dementia. PMID: 38098743
36. Ferruginol prevents degeneration of dopaminergic neurons by enhancing clearance of α-synuclein in neuronal cells. PMID: 34678438
37. Outlook of SNCA (alpha-synuclein) transgenic fly models in delineating the sequel of mitochondrial dysfunction in Parkinson's disease. PMID: 39954798
38. Similarity of the non-amyloid-β component and C-terminal tail of monomeric and tetrameric alpha-synuclein with 14-3-3 sigma. PMID: 34667532
39. Misfolded GBA/β-glucocerebrosidase impairs ER-quality control by chaperone-mediated autophagy in Parkinson disease. PMID: 35482760
40. Reducing INS-IGF1 signaling protects against non-cell autonomous vesicle rupture caused by SNCA spreading. PMID: 31354022
41. Clustering lysosomes around the MTOC: a promising strategy for SNCA/alpha-synuclein breakdown leading to parkinson disease treatment. PMID: 39401987
42. Piperine promotes autophagy flux by P2RX4 activation in SNCA/alpha-synuclein-induced Parkinson disease model. PMID: 34092198
43. Holocranohistochemistry enables the visualization of α-synuclein expression in the murine olfactory system and discovery of its systemic anti-microbial effects. PMID: 28477284
44. Investigation of somatic CNVs in brains of synucleinopathy cases using targeted SNCA analysis and single cell sequencing. PMID: 31870437
45. Autophagy inhibition promotes SNCA/alpha-synuclein release and transfer via extracellular vesicles with a hybrid autophagosome-exosome-like phenotype. PMID: 29198173
46. A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation. PMID: 26649942
47. Genomic predictors of remission to antidepressant treatment in geriatric depression using genome-wide expression analyses: a pilot study. PMID: 26471432
48. Abnormal triaging of misfolded proteins by adult neuronal ceroid lipofuscinosis-associated DNAJC5/CSPα mutants causes lipofuscin accumulation. PMID: 35506243
49. Drosophila aux orchestrates the phosphorylation-dependent assembly of the lysosomal V-ATPase in glia and contributes to SNCA/alpha-synuclein degradation. PMID: 39878136
50. SNCA but not DNM3 and GAK modifies age at onset of LRRK2-related Parkinson's disease in Chinese population. PMID: 31041581
51. IFNB/interferon-β regulates autophagy via a MIR1-TBC1D15-RAB7 pathway. PMID: 31958036
52. Whole-genome sequencing to identify rare variants in East Asian patients with dementia with Lewy bodies. PMID: 39572598
53. Lysosomal dysfunction in neurodegeneration: the role of ATP13A2/PARK9. PMID: 22561922
54. The secret life of degradative lysosomes in axons: delivery from the soma, enzymatic activity, and local autophagic clearance. PMID: 31533518
55. Molecular chaperones and Parkinson's disease. PMID: 34626793
56. LGALS3 (galectin 3) mediates an unconventional secretion of SNCA/alpha-synuclein in response to lysosomal membrane damage by the autophagic-lysosomal pathway in human midbrain dopamine neurons. PMID: 34612142
57. MicroRNA-7 regulates melanocortin circuits involved in mammalian energy homeostasis. PMID: 36175420
58. The Role of Alpha-Synuclein and Other Parkinson's Genes in Neurodevelopmental and Neurodegenerative Disorders. PMID: 32785033
59. Tyrosine kinase inhibition facilitates autophagic SNCA/alpha-synuclein clearance. PMID: 23787811
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