DVV02802 Nirsevimab蛋白抗体
一、中文名称：尼塞韦单抗
二、产品描述：Nirsevimab (MEDI8897) 是一种具有修饰 Fc 区的重组人呼吸道合胞病毒 (RSV) 单克隆抗体。Nirsevimab 高效靶向 RSV-B ，Kd 值为 1.5 nM。Nirsevimab 可用于预防 RSV 感染。
三、产品详情：
货号：DVV02802
表达系统：Mammalian Cells
种属反应性：HRSV-A
宿主：Humanized
同种型：IgG1, kappa
克隆类型：Monoclonal
靶标：F, Fusion glycoprotein F0, Fusion glycoprotein F2,
p27, Intervening segment, Pep27, Peptide 27, Fusion glycoprotein F1
浓度：3.67 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture
supernatant.
Accession 号：P03420
克隆号：Nirsevimab
应用：Research Grade Biosimilar
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated
freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months.
Store at -80°C long term.
别名：MEDI-8897, MEDI8897, CAS: 1989556-22-0
四、参考文献：
A phase I, randomized, placebo-controlled trial to evaluate the pharmacokinetics, safety, and tolerability of nirsevimab in healthy Chinese adults. PMID: 39736101
180-day efficacy of nirsevimab against hospitalisation for respiratory syncytial virus lower respiratory tract infections in infants (HARMONIE): a randomised, controlled, phase 3b trial. PMID: 40379431
The efficacy and safety of nirsevimab for the prevention of RSV infection among infants: A systematic review and meta-analysis. PMID: 37082704
Monoclonal Antibody for the Prevention of Respiratory Syncytial Virus in Infants and Children: A Systematic Review and Network Meta-analysis. PMID: 36800182
Systematic Review of the Efficacy and Safety of RSV-Specific Monoclonal Antibodies and Antivirals in Development. PMID: 39209729
详情请咨询Antibodysystem中国授权总代理-武汉佰乐博生物技术有限公司
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