佰乐博生物蛋白抗体推荐Research Grade Solitomab (索利托单抗) 研究级别药物对照抗体
一、中文名称：索利托单抗
二、产品描述：Solitomab (AMG 110) 是一种双特异性的抗 CD3 和抗上皮细胞粘附分子 (EpCAM) 抗体。Solitomab 可用于原发性子宫癌和卵巢癌肉瘤的研究。
三、产品详情：
货号：DHD17407
表达系统：Mammalian Cells
种属反应性：Human
宿主：Mouse
同种型：(scFv - kappa - heavy)-(scFv - heavy - kappa)
克隆类型：Monoclonal
靶标：Epithelial glycoprotein 314, hEGP314, Major gastrointestinal tumor - associated protein GA733 - 2, EGP314, TACSTD1, Adenocarcinoma - associated antigen, TROP1, EPCAM, Epithelial glycoprotein, KS 1/4 antigen, Tumor - associated calcium signal transducer 1, M4S1, CD326, Ep - CAM, EGP, Epithelial cell adhesion molecule, M1S2, KSA, Cell surface glycoprotein Trop - 1, GA733 - 2, Epithelial cell surface antigen, MIC18, T3E, T - cell surface antigen T3/Leu - 4 epsilon chain, CD3e, CD3E, T - cell surface glycoprotein CD3 epsilon chain
浓度：1.5 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS - PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession 号：P16422 & P07766
克隆号：Solitomab
应用：Research Grade Biosimilar
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze - thaw cycles. Store at 4°C short term (1 - 2 weeks). Store at -20°C 12 months. Store at -80°C long term.
别名：Bispecific, MT110, AMG 110, AMG - 110, AMG110, CAS: 1005198 - 65 - 1
四、参考文献：
1. A Novel Hydrogel-Based 3D In Vitro Tumor Panel of 30 PDX Models Incorporates Tumor, Stromal and Immune Cell Compartments of the TME for the Screening of Oncology and Immuno-Therapies. PMID: 37190054
2. Solitomab, an EpCAM/CD3 bispecific antibody construct (BiTE), is highly active against primary uterine and ovarian carcinosarcoma cell lines in vitro. PMID: 26474755
3. 10 years of BiTE immunotherapy: an overview with a focus on pancreatic cancer. PMID: 39759138
4. A multicenter phase 1 study of solitomab (MT110, AMG 110), a bispecific EpCAM/CD3 T-cell engager (BiTE) antibody construct, in patients with refractory solid tumors. PMID: 30221040
5. EpCAM expression in esophageal cancer and its correlation with immunotherapy of solitomab. PMID: 34012588
6. Novel Fab-peptide-HLA-I fusion proteins for redirecting pre-existing anti-CMV T cell immunity to selective eliminate carcinoma cells. PMID: 37180637
7. Solitomab, an epithelial cell adhesion molecule/CD3 bispecific antibody (BiTE), is highly active against primary chemotherapy-resistant ovarian cancer cell lines in vitro and fresh tumor cells ex vivo. PMID: 25251053
8. Solitomab, an EpCAM/CD3 bispecific antibody construct (BiTE), is highly active against primary uterine serous papillary carcinoma cell lines in vitro. PMID: 26272866
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