佰乐博生物蛋白抗体推荐Research Grade Aflibercept 研究级别药物对照抗体，阿柏西普
一、中文名称：阿柏西普
二、产品描述：Aflibercept（阿柏西普）是一种全人类的重组融合蛋白，由VEGF受体1的第二免疫球蛋白（Ig）结合域和VEGF受体2的第三Ig结合域组成，与人类IgG1的Fc区融合。Aflibercept能和所有VEGF-A异构体、VEGF-B，还能够与胎盘生长因子（PlGF）结合，并对VEGF显示出非常高的亲和力，亲和力（Kd）达到0.5 pM，能抑制新生血管的增长。可用于多种眼部血管新生引起的疾病研究。
三、产品详情：
货号：DHD12629
表达系统：Mammalian Cells
种属反应性：Human
宿主：Human
同种型：IgG1-Fc
克隆类型：Monoclonal
靶标：Vascular endothelial growth factor A, VPF, VEGFA, VEGF, Vascular permeability factor, VEGF-A
浓度：2.37 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession 号：P15692
克隆号：Aflibercept
应用：Research Grade Biosimilar
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
别名：CAS: 862111-32-8
四、参考文献：
1. The Efficacy, Safety, and Efficiency of the Off-Label Use of Bevacizumab in Patients Diagnosed With Age-Related Macular Degeneration: Protocol for a Systematic Review and Meta-Analysis. PMID: 37294608
2. A phase Ib study of capecitabine and ziv-aflibercept followed by a phase II single-arm expansion cohort in chemotherapy refractory metastatic colorectal cancer. PMID: 31675952
3. Safety and effectiveness of aflibercept in combination with FOLFIRI in Korean patients with metastatic colorectal cancer who received oxaliplatin-containing regimen. PMID: 35344080
4. Anatomical and functional outcomes following switching from aflibercept to ranibizumab in neovascular age-related macular degeneration in Europe: SAFARI study. PMID: 31383649
5. Risk of antiangiogenic adverse events in metastatic colorectal cancer patients receiving aflibercept in combination with chemotherapy: A meta-analysis. PMID: 37657052
6. Correlation between Diabetic Retinopathy Severity and Oxygen Metabolism in Patients with Diabetic Macular Edema during Treatment with Intravitreal Aflibercept. PMID: 31715608
7. Prevalence and characteristics of macular atrophy in eyes with neovascular age-related macular degeneration. A study from a long-term observational dataset: the Fight Retinal Blindness! project. PMID: 31843790
8. A systemic review and meta-analysis of Aflibercept plus FOLFIRI regimen as a second-line treatment for metastatic colorectal cancer: A PRISMA compliant pooled analysis of randomized controlled trials and single arm studies to assess efficacy and safety. PMID: 37257732
9. A phase II evaluation of aflibercept in the treatment of recurrent or persistent endometrial cancer: a Gynecologic Oncology Group study. PMID: 22922531
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