Research Grade Tulinercept (DHB94412)
一、中文名称：Research Grade Tulinercept (DHB94412) ，研究级Tulinercept类似物
二、产品描述
Tulinercept (OPRX-106) 是一种单克隆抗体，属于TNF-α抑制剂(肿瘤坏死因子α抑制剂)，Tulinercept 可用于各种生化研究。
三、产品详情
名称：Research Grade Tulinercept (DHB94412)
别名：OPRX-106,PRX-106,TNFR-Fc, CAS: 1623177-41-2
货号：DHB94412
表达系统：Mammalian Cells
种属反应性：Human
同种型：Fusion - [TNFRSF1B (tumor necrosis factor receptor (TNFR) superfamily member 1B, TNFBR, p75, CD120b)]2 - IGHG1 Fc (Fragment constant)
靶标：TNF, Tumor necrosis factor ligand superfamily member 2, N-terminal fragment, ICD2, NTF, TNF-a, TNF-alpha, Tumor necrosis factor, TNFSF2, TNFA, Cachectin, ICD1
浓度：1 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession号：P01375
克隆号：Tulinercept
应用：Research Grade Biosimilar
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
四、参考文献
Transmembrane TNF-alpha: structure, function and interaction with anti-TNF agents.PMID:20194223
TNF-alpha protects from exacerbated myocarditis and cardiac death by suppressing expansion of activated heart-reactive CD4+ T cells.PMID:37879102
Complexity of TNF-alpha Signaling in Heart Disease.PMID:33053859
The Clinical Response of Upadacitinib and Risankizumab Is Associated With Reduced Inflammatory Bowel Disease Anti-TNF-alpha Inadequate Response Mechanisms.PMID:36515243
Role of TNF-alpha-induced m6A RNA methylation in diseases: a comprehensive review.PMID:37554306
Reconciling intrinsic properties of activating TNF receptors by native ligands versus synthetic agonists.PMID:37795079
Selective Targeting of TNF Receptors as a Novel Therapeutic Approach.PMID:32528961
TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects.PMID:26117714
Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral Reservoirs.PMID:28358311
The Use of TNF-alpha Inhibitors in Active Ankylosing Spondylitis Treatment.PMID:38952586
Bone and TNF in rheumatoid arthritis: clinical implications.PMID:26557382
TNF receptors in chronic lymphocytic leukemia.PMID:8025522
TNF-alpha gene polymorphism: clinical and biological implications.PMID:10891887
Differential TNF-signaling in chronic inflammatory disorders.PMID:15354874
TNF pathophysiology in murine models of chronic inflammation and autoimmunity.PMID:15852247
The Balance of TNF Mediated Pathways Regulates Inflammatory Cell Death Signaling in Healthy and Diseased Tissues.PMID:32671059
Could Mucosal TNF Transcript as a Biomarker Candidate Help Optimize Anti-TNF Biological Therapy in Patients With Ulcerative Colitis?PMID:35663996
Drugs for Autoimmune Inflammatory Diseases: From Small Molecule Compounds to Anti-TNF Biologics.PMID:28785220
Palmitoylation is required for TNF-R1 signaling.PMID:31382980
TNF-alpha gene polymorphisms: association with age-related macular degeneration in Russian population.PMID:30662836
TNF-alpha Antagonists and Immunization.PMID:21455717
TNF- induces mitochondrial dysfunction to drive NLRP3/Caspase-1/GSDMD-mediated pyroptosis in MCF-7 cells.PMID:39468189
Transmembrane TNF-alpha reverse signaling leading to TGF-beta production is selectively activated by TNF targeting molecules: Therapeutic implications.PMID:27888159
Primary Failure to an Anti-TNF Agent in Inflammatory Bowel Disease: Switch (to a Second Anti-TNF Agent) or Swap (for Another Mechanism of Action)?PMID:34830595
Formation and clearance of TNF-TNF inhibitor complexes during TNF inhibitor treatment.PMID:37859583
TNF signaling: early events and phosphorylation.PMID:18063842
TNF-alpha/TNF-R System May Represent a Crucial Mediator of Proliferative Synovitis in Hemophilia A.PMID:31261789
Transmembrane TNF-dependent uptake of anti-TNF antibodies.PMID:28323513
C-tag TNF: a reporter system to study TNF shedding.PMID:33082141
TNF deficiency causes alterations in the spatial organization of neurogenic zones and alters the number of microglia and neurons in the cerebral cortex.PMID:31505254
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