一、中文名称：Research Grade Lenercept (DHB94410)，研究级Lenercept类似物
二、产品描述
Lenercept (Ro 45-2081) 是一种重组融合蛋白，由肿瘤坏死因子受体（TNFR）与人免疫球蛋白G1（IgG1）的Fc区域融合而成。这种结构使得Lenercept能够结合并中和TNF，从而阻止其与细胞表面的TNF受体结合，减少炎症反应。
三、产品详情
名称：Research Grade Lenercept (DHB94410)
别名：TNFR55-Ig1,TNFRSF1A-Fc,p55TNF-R:Ig, CAS: 156679-34-4
货号：DHB94410
表达系统：Mammalian Cells
种属反应性：Human
同种型：Fusion - [TNFRSF1A (tumor necrosis factor receptor (TNFR) superfamilly member 1A, TNFAR, TNF-RI, TNF-R-I, p55, CD120a)]2 - IGHG1 Fc (Fragment constant)
靶标：TNF, Tumor necrosis factor ligand superfamily member 2, N-terminal fragment, ICD2, NTF, TNF-a, TNF-alpha, Tumor necrosis factor, TNFSF2, TNFA, Cachectin, ICD1
浓度：1 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession号：P01375
克隆号：Lenercept
应用：Research Grade Biosimilar
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
四、参考文献：
Lenercept (p55 tumor necrosis factor receptor fusion protein) in severe sepsis and early septic shock: a randomized, double-blind, placebo-controlled, multicenter phase III trial with 1,342 patients.PMID:11373411
Intravenous human recombinant tumor necrosis factor receptor p55-Fc IgG1 fusion protein, Ro 45-2081 (lenercept): results of a dose-finding study in rheumatoid arthritis.PMID:14528504
Animal pharmacokinetics of the tumor necrosis factor receptor-immunoglobulin fusion protein lenercept and their extrapolation to humans.PMID:9884305
TNF neutralization in MS: results of a randomized, placebo-controlled multicenter study. The Lenercept Multiple Sclerosis Study Group and The University of British Columbia MS/MRI Analysis Group.PMID:10449104
Intravenous human recombinant tumor necrosis factor receptor p55-Fc IgG1 fusion protein Ro 45-2081 (lenercept): a double blind, placebo controlled dose-finding study in rheumatoid arthritis.PMID:12672184
Anti-inflammatory response after infusion of p55 soluble tumor necrosis factor receptor fusion protein for severe sepsis.PMID:12799209
Adalimumab-associated multiple sclerosis.PMID:17216704
Therapeutic approaches in multiple sclerosis: lessons from failed and interrupted treatment trials.PMID:12102646
Tumour Necrosis Factor Neutralization in MS: A Cautionary Tale.PMID:21689500
[Multiple sclerosis. Current review of failed and discontinued clinical trials of drug treatment].PMID:10996910
Importance of underlying mechanism and genotype on outcome of sepsis trials.PMID:11373447
TNF-alpha-targeted therapy in rheumatoid arthritis.PMID:10339773
The use of TNF-alpha blocking agents in rheumatoid arthritis: an overview.PMID:15013927
USAN Council. List No.407. New names. Lenercept.PMID:9758530
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