一、中文名称：Research Grade Ipafricept (DHK29201)，研究级Ipafricept 类似物
二、产品描述
Ipafricept (OMP-54F28; FZD8-Fc) 是第一类重组融合蛋白 (recombinant fusion protein)，由人卷曲-8 受体的细胞外部分与人 IgG1 Fc 片段融合，该片段结合 Wnt 配体，阻断 Wnt 信号传导。Ipafricept 在胰腺癌小鼠模型中与 Gemcitabine (HY-17026) 联合使用可降低肿瘤生长，减少肝脏和肺转移。Ipafricept 表现出良好耐受性的实体肿瘤抑制作用，比如硬纤维瘤、生殖细胞癌、卵巢癌。。
三、产品详情
名称：Research Grade Ipafricept (DHK29201)
别名：FZD8-Fc,Frizzled8 Fc,OMP-54F28, CAS: 1391727-24-4
货号：DHK29201
表达系统：Mammalian Cells
种属反应性：Human
同种型：Fusion - [FZD8 (frizzled class receptor 8, frizzled family receptor 8, Frizzled-8)]2 - IGHG1 Fc (Fragment constant)
靶标：Wnt ligands
浓度：1 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
克隆号：Ipafricept
应用：Research Grade Biosimilar
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
四、参考文献：
详情请咨询Antibodysystem中国授权总代理-武汉佰乐博生物技术有限公司
Multi?layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β?catenin signaling activation (Review).PMID:29786110
Phase Ib Study of Wnt Inhibitor Ipafricept with Gemcitabine and nab-paclitaxel in Patients with Previously Untreated Stage IV Pancreatic Cancer.PMID:32694153
A phase 1b dose escalation study of ipafricept (OMP54F28) in combination with paclitaxel and carboplatin in patients with recurrent platinum-sensitive ovarian cancer.PMID:31174889
A First-in-Human Phase I Study of the Anticancer Stem Cell Agent Ipafricept (OMP-54F28), a Decoy Receptor for Wnt Ligands, in Patients with Advanced Solid Tumors.PMID:28954784
Hepatocellular Carcinoma: Etiology and Current and Future Drugs.PMID:31024205
Molecular genetics and targeted therapy of WNT-related human diseases (Review).PMID:28731148
WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death.PMID:28691093
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