二、产品描述
Luspatercept (ACE-536) 是一种重组修饰的 ActRIIB 融合蛋白，可与转化生长因子 β 超家族配体结合。Luspatercept 增加红细胞数量，促进红细胞前体成熟。Luspatercept 与 GDF11 结合，抑制 Smad2/3 信号通路。Luspatercept 可用于贫血的研究。。
三、产品详情
名称：Research Grade Luspatercept (DHB63001)
别名：ACE-536,luspatercept–aamt, CAS: 1373715-00-4
货号：DHB63001
表达系统：Mammalian Cells
种属反应性：Human
同种型：Fusion - [ACVR2B (activin A receptor type 2B, ActR-IIB, ActRIIB)]2 - IGHG1 Fc (Fragment constant)
靶标：GDF11, BMP-11, BMP11, Growth/differentiation factor 11, GDF-11, Bone morphogenetic protein 11
浓度：7 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession号：O95390
克隆号：Luspatercept
应用：Research Grade Biosimilar
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
四、参考文献：
Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes.PMID:31914241
Luspatercept.PMID:37094054
Luspatercept.PMID:34648251
A Phase 3 Trial of Luspatercept in Patients with Transfusion-Dependent beta-Thalassemia.PMID:32212518
Efficacy and safety of luspatercept versus epoetin alfa in erythropoiesis-stimulating agent-naive, transfusion-dependent, lower-risk myelodysplastic syndromes (COMMANDS): interim analysis of a phase 3, open-label, randomised controlled trial.PMID:37311468
Luspatercept: First Approval.PMID:31939073
Luspatercept in Myelodysplastic Syndromes: Who and When?PMID:32089218
Luspatercept in low-risk myelodysplastic syndromes: a paradigm shift in treatment strategies.PMID:38555469
Luspatercept in the treatment of lower-risk myelodysplastic syndromes.PMID:33511859
Luspatercept.PMID:32809470
Luspatercept for the treatment of anaemia in non-transfusion-dependent beta-thalassaemia (BEYOND): a phase 2, randomised, double-blind, multicentre, placebo-controlled trial.PMID:36007538
Management of luspatercept therapy in patients with transfusion-dependent beta-thalassaemia.PMID:37037668
Luspatercept for beta-thalassemia: beyond red blood cell transfusions.PMID:34404288
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