一、中文名称：Research Grade Latikafusp (DHJ59501)抗体
二、产品描述
Latikafusp (AMG 256)是一种双功能融合蛋白，包含靶向PD-1的抗体和IL-21突变蛋白，旨在向PD-1+细胞提供IL-21通路刺激。Latikafusp可以启动和延长细胞毒性和记忆T细胞的活性，并诱导抗肿瘤免疫。Latikafusp具有用于实体瘤研究的潜力。Latikafusp可导致免疫原性介导的反应的产生。
三、产品详情
名称：Research Grade Latikafusp (DHJ59501)
别名：Bispecific antibody, AMG 256, AMG-256, AMG256, CAS: 2552814-07-8
货号：DHJ59501
表达系统：Mammalian Cells
种属反应性：Human
宿主：Human
同种型：IgG1-lambda2
克隆类型：Monoclonal
靶标：IL21R, NILR, Interleukin-21 receptor, IL-21R, IL-21 receptor, CD360, Novel interleukin receptor, Programmed cell death protein 1, Protein PD-1, hPD-1, PD1, PDCD1, CD279
浓度：1.1 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession号：Q9HBE5 & Q15116
克隆号：Latikafusp
应用：Research Grade Biosimilar
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
四、参考文献：
Design and rationale of a phase 1 study evaluating AMG 256, a novel, targeted, PD-1 antibody x IL-21 mutein bifunctional fusion protein, in patients with advanced solid tumors. PMID: 35365319
Design and rationale of a phase 1 study evaluating AMG 256, a novel, targeted, IL-21 receptor agonist and anti-PD-1 antibody, in patients with advanced solid tumors. PMID: 33177001
Translatability of findings from cynomolgus monkey to human suggests a mechanistic role for IL-21 in promoting immunogenicity to an anti-PD-1/IL-21 mutein fusion protein. PMID: 38383214
详情请咨询Antibodysystem中国授权总代理-武汉佰乐博生物技术有限公司
网址：https://www.antibodysystem.com/index/search?wd=DHJ59501
武汉佰乐博生物技术有限公司作为法国Antibodysystem品牌亚洲区授权总代理。提供近3万种蛋白、抗体等核心生命科学试剂，旨在为生命科学科研工作者提供专业、全面、可靠的试剂产品。
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