一、中文名称：InVivoMAb Anti-Mouse CD198/CCR8 Antibody (Iv0256) (VME85601)，抗小鼠CCR8抗体
二、产品描述
CC趋化因子受体8（CCR8）主要在淋巴组织中表达，也在肾小球足细胞和人脐静脉内皮细胞（HUVECs）中发现。CCR8与Th2淋巴细胞相关，这些细胞对过敏反应至关重要，并且在淋巴细胞的激活、迁移、增殖和分化以及过敏性疾病中发挥作用。CCR8结合到CCL1（也称为I-309）和CCL16（也称为肝脏表达趋化因子）。它还对三种病毒来源的趋化因子具有高亲和力：vMIP-I、vMIP-II和vMCC-I。
三、产品详情
名称：InVivoMAb Anti-Rat CD198/CCR8 Antibody (Iv0256) (VRE85601)
别名： CC chemokine receptor 8,CD198,ChemR1,CKRL1,CKR-L1,CKRL1,CY6,GPRCL1,GPRCY6,GPR-CY6,TER-1
货号：VRE85601
种属反应性：Rat
宿主：Mouse
同种型：IgG2a, kappa
克隆类型：Monoclonal
靶标：C-C motif chemokine receptor 8, Ccr8
浓度：1 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession号：D4ADE0
克隆号：Iv0256
应用：ELISA, Neutralization
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
四、参考文献：
CCR8-targeted specific depletion of clonally expanded Treg cells in tumor tissues evokes potent tumor immunity with long-lasting memory. PMID: 35140181
Chemokine Receptor-Targeted Therapies: Special Case for CCR8. PMID: 35158783
Differential expression of CCR8 in tumors versus normal tissue allows specific depletion of tumor-infiltrating T regulatory cells by GS-1811, a novel Fc-optimized anti-CCR8 antibody. PMID: 36352891
S-531011, a Novel Anti-Human CCR8 Antibody, Induces Potent Antitumor Responses through Depletion of Tumor-Infiltrating CCR8-Expressing Regulatory T Cells. PMID: 37420296
Blocking CCL8-CCR8-Mediated Early Allograft Inflammation Improves Kidney Transplant Function. PMID: 35973731
CD4(+)CCR8(+) Tregs in ovarian cancer: a potential effector Tregs for immune regulation. PMID: 37950246
Oxamate enhances the efficacy of CAR-T therapy against glioblastoma via suppressing ectonucleotidases and CCR8 lactylation. PMID: 37770937
The impact of CCR8+ regulatory T cells on cytotoxic T cell function in human lung cancer. PMID: 35354899
TGF-beta-induced CCR8 promoted macrophage transdifferentiation into myofibroblast-like cells. PMID: 35377281
CCR8 is a new therapeutic target in cutaneous T-cell lymphomas. PMID: 35201316
Immunotherapy Targeting CCR8+ Regulatory T Cells Induces Antitumor Effects via Dramatic Changes to the Intratumor CD8+ T Cell Profile. PMID: 37350632
Cutting Edge: CCR8 Signaling Regulates IL-25- and IL-33-Responsive Skin Group 2 Innate Lymphoid Cell Migration and Function. PMID: 37921466
C(8)Mab-3: An Anti-Mouse CCR8 Monoclonal Antibody for Immunocytochemistry. PMID: 35377236
CCR8 Signaling via CCL1 Regulates Responses of Intestinal IFN-gamma Producing Innate Lymphoid CelIs and Protects From Experimental Colitis. PMID: 33613532
CCR8 blockade primes anti-tumor immunity through intratumoral regulatory T cells destabilization in muscle-invasive bladder cancer. PMID: 32367308
Role of chemokines in the crosstalk between tumor and tumor-associated macrophages. PMID: 36173487
The Chemokine Receptor CCR8 Is a Target of Chimeric Antigen T Cells for Treating T Cell Malignancies. PMID: 35693763
详情请咨询Antibodysystem中国授权总代理-武汉佰乐博生物技术有限公司
网址：https://www.antibodysystem.com/product/21632.html
武汉佰乐博生物技术有限公司作为法国Antibodysystem品牌亚洲区授权总代理。提供近3万种蛋白、抗体等核心生命科学试剂，旨在为生命科学科研工作者提供专业、全面、可靠的试剂产品。
试剂 | 耗材 | 定制 | 实验服务 | 供应链
免费热线：027-65279366 /18108604356
