一、中文名称：Anti-Mouse CD152/CTLA4 Antibody (H11)，抗小鼠CTLA4抗体
二、产品描述
CTLA-4是一种33 kDa的细胞表面受体,也称为CD152，由属于免疫球蛋白超家族CD28家族的Ctla4基因编码。CTLA-4在活化的T淋巴细胞和B淋巴细胞上表达。CTLA-4在结构上类似于T细胞共刺激蛋白CD28，两种分子都与B7家族成员B7-1 (CD80)和B7-2 (CD86)结合。在与配体结合时，CTLA-4负调节细胞介导的免疫反应。CTLA-4在诱导和/或维持免疫耐受、胸腺细胞发育和保护性免疫调节中起作用。CTLA-4在免疫下调中的关键作用已经在CTLA-4缺陷小鼠中得到证实，这些小鼠在3-5周龄时由于淋巴增生性疾病的发展而死亡。CTLA-4是目前肿瘤免疫检查点治疗的热门靶点之一。
三、相关产品
Anti-Mouse CD152/CTLA4 Antibody (H11) (FMD17210)
Anti-Mouse CD152/CTLA4 Antibody (H11), PE (FMD17212)
Anti-Mouse CD152/CTLA4 Antibody (H11), PerCP (FMD17214)
Anti-Mouse CD152/CTLA4 Antibody (H11), APC (FMD17213)
Anti-Mouse CD152/CTLA4 Antibody (H11), FITC (FMD17211)
四、产品详情
名称：Anti-Mouse CD152/CTLA4 Antibody (H11) (FMD17210)
别名：Celiac Disease 3，Ligand And Transmembrane Spliced Cytotoxic T Lymphocyte Associated Antigen 4，Cytotoxic T-Lymphocyte Protein 4，CD152，Cytotoxic T-lymphocyte-associated antigen 4，CTLA4，CTLA-4，Cytotoxic T-Lymphocyte Associated Protein 4，Insulin-Dependent Diabetes Mellitus 12，Cytotoxic T Lymphocyte Associated Antigen 4 Short Spliced Form，Cytotoxic T-Lymphocyte-Associated Serine Esterase-4，CD152 Isoform，CD152 Antigen，CELIAC3，IDDM12，ALPS5，GRD4，GSE，CD，CTLA-4 Antigen
货号：FMD17210
种属反应性：Mouse
宿主：Mouse
同种型：VHH, mFc
克隆类型：Monoclonal
偶联物：Unconjugated
靶标：Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4, CTLA-4, CD152, Ctla4
浓度：1 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession号：P09793
克隆号：H11
应用：ELISA, FCM
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term. (FMD17210)
五、参考文献：
CTLA-4 (CD152) and its involvement in autoimmune disease. PMID: 16126511
Management of immune-related adverse events and kinetics of response with ipilimumab. PMID: 22614989
Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation. PMID: 35999394
Genetic analysis of the exon 1 position 49 CD152 dimorphism in multiple sclerosis. PMID: 17920697
CD152 (CTLA-4) determines CD4 T cell migration in vitro and in vivo. PMID: 19479036
Molecular and Functional Analyses of the Primordial Costimulatory Molecule CD80/86 and Its Receptors CD28 and CD152 (CTLA-4) in a Teleost Fish. PMID: 35784316
Ipilimumab. PMID: 24047771
Surface CD152 (CTLA-4) expression and signaling dictates longevity of CD28null T cells. PMID: 19380781
HLA-G and CD152 Expression Levels Encourage the Use of Umbilical Cord Tissue-Derived Mesenchymal Stromal Cells as an Alternative for Immunosuppressive Therapy. PMID: 35456019
CD152 and PD-1 down-regulation on CD8 T cells is associated with human acute liver allograft rejection. PMID: 25498082
CTLA4 gene variants in autoimmunity and cancer: a comparative review. PMID: 21931200
CTLA4 DNA methylation is associated with CTLA-4 expression and predicts response to immunotherapy in head and neck squamous cell carcinoma. PMID: 37415208
CTLA4 Promotes Tyk2-STAT3-Dependent B-cell Oncogenicity. PMID: 28716895
CTLA4 gene polymorphism and autoimmunity. PMID: 15790353
Molecular and Cellular Functions of CTLA-4. PMID: 32185705
Abatacept for treatment-refractory pediatric CTLA4-haploinsufficiency. PMID: 34116213
Nanobody-based CTLA4 inhibitors for immune checkpoint blockade therapy of canine cancer patients. PMID: 34675296
CTLA4-Ig protects tacrolimus-induced oxidative stress via inhibiting the AKT/FOXO3 signaling pathway in rats. PMID: 37157174
CTLA4-Mediated Immunosuppression in Glioblastoma is Associated with the Infiltration of Macrophages in the Tumor Microenvironment. PMID: 34992419
Chimeric CTLA4-CD28-CD3z T Cells Potentiate Antitumor Activity Against CD80/CD86-Positive B Cell Malignancies. PMID: 33868277
Mixed-ligand organometallic polymers containing the "Pd(2)(dmb)2(2+)" fragment: properties of the [Pd2(dmb)2(diphos)2+](n) polymers/oligomers in solution and in the solid state. PMID: 15310210
Culture of in vitro fertilized bovine embryos with bovine oviductal epithelial cells, Buffalo rat liver (BRL) cells, or BRL-cell-conditioned medium. PMID: 16727807
Bonding behavior of Co(CO)(3)L (L = CO, PPh(3)) building blocks in platinum-cobalt carbonyl clusters. PMID: 11925164
The clinical significance of Aspergillus isolation from airway samples in critically ill patients. PMID: 19957781
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