一、中文名称：Anti-Human TSHR/LGR3 Antibody (K1-70)(FHD18120)，抗人促甲状腺素受体

二、产品描述

促甲状腺素受体（Thyrotropin receptor, TSHR）是一种细胞表面糖蛋白受体，属于A类G蛋白偶联受体（GPCRs）超家族的LGR亚家族，并与Gs蛋白相连接。TSHR主要在甲状腺组织中表达，但其mRNA和蛋白也存在于神经组织、免疫细胞、眼肌、骨骼、脂肪细胞、红细胞、卵巢和肝脏等部位。TSHR接受促甲状腺激素（Thyrotropin, TSH）信号刺激后，启动偶联信号通路，促进下游效应基因的表达，刺激细胞生成甲状腺激素（T4）和三碘甲状腺激素（T3），对甲状腺的生长和功能至关重要。

三、产品详情

名称：Anti-Human TSHR/LGR3 Antibody (K1-70) (FHD18120)

别名：hyroid-stimulating hormone receptor, TSH-R, TSHR, Thyrotropin receptor, LGR3, RHD18102

货号：FHD18120

种属反应性：Human

宿主：Mouse

同种型：IgG2a, lambda

克隆类型：Monoclonal

偶联物：Unconjugated

靶标：Thyroid-stimulating hormone receptor, TSH-R, TSHR, Thyrotropin receptor, LGR3, RHD18102

浓度：0.56 mg/ml

内毒素水平：Please contact with the lab for this information.

纯度：>95% as determined by SDS-PAGE.

纯化方式：Protein A/G purified from cell culture supernatant.

Accession号：P16473

克隆号：K1-70

应用：Blocking, ELISA, FCM

状态：Liquid

保存溶液：0.01M PBS, pH 7.4.

稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

四、参考文献：

Mechanisms of Action of TSHR Autoantibodies. PMID: 26361260

Modulation of TSHR signaling by posttranslational modifications. PMID: 17524661

Central Tolerance Mechanisms to TSHR in Graves' Disease: Contributions to Understand the Genetic Association. PMID: 30396220

TSHR-based chimeric antigen receptor T cell specifically deplete auto-reactive B lymphocytes for treatment of autoimmune thyroid disease. PMID: 37690235

Controversial constitutive TSHR activity: patients, physiology, and in vitro characterization. PMID: 24845969

Genetics of Graves' Disease: Special Focus on the Role of TSHR Gene. PMID: 26361261

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