一、中文名称：Anti-Human F7/Coagulation factor VII Antibody(3A4)(RHC35902)， 重组人凝血因子7抗体
二、产品描述
凝血因子VII是一种依赖维生素K的因子，对止血至关重要。这种因子在血液中以酶原形式循环，并通过因子IXa、因子Xa、因子XIIa或凝血酶进行轻微蛋白水解后转化为活性形式。当因子VII被激活时，会产生一个包含催化结构域的重链和一个包含两个表皮生长因子（EGF）样结构域的轻链，这两条链通过二硫键连接在一起。在因子III和钙离子存在的情况下，活化的因子VII进一步通过将因子IX转化为因子IXa和/或将因子X转化为因子Xa来激活凝血级联反应。F7生成缺陷可导致凝血障碍。
三、产品详情
名称：Anti-Human F7/Coagulation factor VII Antibody (3A4) (RHC35902)
别名：Coagulation factor VII; Eptacog alfa; F7; FVII coagulation protein; SPCA
货号：RHC35902
表达系统：Mammalian Cells
种属反应性：Human
宿主：Mouse
同种型：IgG2a, kappa
克隆类型：Monoclonal
靶标：F7, Coagulation factor VII, FVII, Proconvertin, Serum prothrombin conversion accelerator, SPCA, Eptacog alfa
浓度：1.32 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession号：P08709
克隆号：3A4
应用：ELISA, WB
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
四、参考文献：
Structures of cytochrome P450 3A4. PMID: 15653318
Cytochrome P-450 3A4: regulation and role in drug metabolism. PMID: 10331074
Predicting drug-drug interactions by electrochemically driven cytochrome P450 3A4 reactions. PMID: 34860476
Approaches for increasing the electrocatalitic efficiency of cytochrome P450 3A4. PMID: 36198256
Drug-drug interactions between triazole antifungal agents used to treat invasive aspergillosis and immunosuppressants metabolized by cytochrome P450 3A4. PMID: 28722255
Influence of cytochrome P450 3A4 and membrane lipid composition on doxorubicin activity. PMID: 36183636
Kinetics of cytochrome P450 3A4 inhibition by heterocyclic drugs defines a general sequential multistep binding process. PMID: 33449875
3A4, a new potential target for B and myeloid lineage leukemias. PMID: 21504388
On the inhibition of cytochrome P450 3A4 by structurally diversified flavonoids. PMID: 34060409
CYP2C9 and 3A4 play opposing roles in bioactivation and detoxification of diphenylamine NSAIDs. PMID: 34748821
Identification of the pharmacogenetic determinants of alfentanil metabolism: cytochrome P-450 3A4. An explanation of the variable elimination clearance. PMID: 1519785
Roles of human cytochrome P450 3A4/5 in dexamethasone 6beta-hydroxylation mediated by liver microsomes and humanized liver in chimeric mice metabolically suppressed with azamulin. PMID: 37031476
No effect of lipoic acid on catalytic activity of cytochrome P450 3A4. PMID: 32712589
A Promising Approach to Treat Psoriasis: Inhibiting Cytochrome P450 3A4 Metabolism to Enhance Desoximetasone Therapy. PMID: 37631230
Late Microaerobic Growth for Efficient Production of Human Cytochrome P450 3A4 in E. coli. PMID: 38047781
Effect of CYP2D6, 2C19, and 3A4 Phenoconversion in Drug-Related Deaths. PMID: 38668482
Differences of Atomic-Level Interactions between Midazolam and Two CYP Isoforms 3A4 and 3A5. PMID: 37836743
Daclatasvir: A Review of Preclinical and Clinical Pharmacokinetics. PMID: 29353349
Could Cytochrome P450 2D6, 3A4 and 3A5 Polymorphisms Explain the Variability in Clinical Response to Clomiphene Citrate of Anovulatory PCOS Women? PMID: 34690927
Cytochromes P450 1A2 and 3A4 Catalyze the Metabolic Activation of Sunitinib. PMID: 29847931
Potent Inhibition of Human Cytochrome P450 3A4 by Biflavone Components from Ginkgo Biloba and Selaginella Tamariscina. PMID: 35295338
Synthesis of 6beta-hydroxy androgens from a 3,5-diene steroid precursor to test for cytochrome P450 3A4-catalyzed hydroxylation of androstenedione. PMID: 37619673
Increasing the Efficiency of Cytochrome P450 3A4 Electrocatalysis Using Electrode Modification with Spatially Ordered Anodic Aluminum Oxide-Based Nanostructures for Investigation of Metabolic Transformations of Drugs. PMID: 36303055
IL-1 inhibition in familial Mediterranean fever: clinical outcomes and expectations. PMID: 36062765
CYP2C19 and 3A4 Dominate Metabolic Clearance and Bioactivation of Terbinafine Based on Computational and Experimental Approaches. PMID: 30925039
Online Enantioselective Capillary Electrophoretic Method for Screening Cytochrome P450 3A4 Inhibitors. PMID: 31773654
Agrimoniin inhibits the activity of CYP1A2, 2D6, and 3A4 in human liver microsomes. PMID: 34806927
Molecular dynamic mechanism(s) of inhibition of bioactive antiviral phytochemical compounds targeting cytochrome P450 3A4 and P-glycoprotein. PMID: 33063648
Inhibition of human cytochrome P450 3A4 by cholesterol. PMID: 21471209
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