一、中文名称：Anti-Mouse CD71/TFRC Antibody (R17 217.1.3/TIB-219)(FMC02010)，鼠CD71/转铁蛋白受体1抗体
二、产品描述
CD71，全称转铁蛋白受体1（Transferrin Receptor 1，TfR1），别称包括TFRC、p90、sTfR等，是一种II型跨膜糖蛋白，由两个90 kDa的亚基通过二硫键形成同源二聚体。CD71通过网格蛋白依赖的内吞作用介导铁离子摄取，维持细胞内铁稳态，对增殖细胞（如造血细胞、肿瘤细胞）和活化免疫细胞（如T细胞、B细胞前体、NK细胞）至关重要。在静息白细胞中表达较低，但在激活或增殖状态下显著上调。此外，CD71在胎盘组织、肌肉（心肌、腓肠肌）及未成熟红细胞中也高表达。功能上，CD71不仅调控铁代谢，还参与肿瘤进展，因其在多种实体瘤中高表达并与不良预后相关。其与转铁蛋白复合物的内吞过程被病原体（如都瓦病毒、疟原虫）利用以入侵细胞，结构研究表明其胞外域顶端为病原体结合的关键区域。CD71还作为抗体药物偶联物（ADC）的靶点，因肿瘤细胞表面异常高表达而成为治疗潜力。研究还发现，CD71表达与促炎因子（如IL-6、IFN-γ）及T细胞活性标志物（CD39、CD25）呈正相关，提示其在免疫调节中的作用。
三、产品详情
名称：Anti-Mouse CD71/TFRC Antibody (R17 217.1.3/TIB-219)(FMC02010)
别名：Transferrin receptor protein 1, TfR1, T9, Trfr, p90, CD71, TFRC, TfR, sTfR, TR
货号：FMC02020
种属反应性：Human, Mouse, Rat
宿主：Mouse
同种型：IgG2a, kappa
克隆类型：Monoclonal
偶联物：Unconjugated
靶标：Transferrin receptor protein 1, TR, TfR, TfR1, Trfr, CD71, Tfrc
浓度：0.8 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS-PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession号：Q62351
克隆号：OX-26
应用：FCM, IF, IHC (P), IP, WB
状态：Liquid
保存溶液：0.01M PBS, pH 7.4.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
四、参考文献：
TFRC upregulation promotes ferroptosis in CVB3 infection via nucleus recruitment of Sp1.PMID:35821227
Exosomes derived from hepatitis B virus-infected hepatocytes promote liver fibrosis via miR-222/TFRC axis.PMID:34978008
MYCN mediates TFRC-dependent ferroptosis and reveals vulnerabilities in neuroblastoma.PMID:34011924
FTO deficiency in older livers exacerbates ferroptosis during ischaemia/reperfusion injury by upregulating ACSL4 and TFRC.PMID:38834654
Inflammation Triggers Chondrocyte Ferroptosis in TMJOA via HIF-1alpha/TFRC.PMID:38766865
METTL14 promotes doxorubicin-induced cardiomyocyte ferroptosis by regulating the KCNQ1OT1-miR-7-5p-TFRC axis.PMID:34648132
Sorting nexin 3 exacerbates doxorubicin-induced cardiomyopathy via regulation of TFRC-dependent ferroptosis.PMID:38045054
Knockdown of ANXA10 induces ferroptosis by inhibiting autophagy-mediated TFRC degradation in colorectal cancer.PMID:37666806
METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke.PMID:38302612
Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated Encephalopathy by Promoting Ferroptosis Through Regulating miR-9-5p/TFRC and GOT1 Axis.PMID:35038133
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