一、中文名称:
Research Grade Briobacept,科研级Briobacept
二、产品描述
Briobacept (BR 3FC) 是一种重组糖蛋白,由 2 个来自 BLyS 受体 (BR3) 和人 IgG1 的 Fc 结构域组成。Briobacept 选择性靶向 BLyS (BAFF),能够诱导 B 细胞凋亡 (apoptosis)。Briobacept 可用于类风湿关节炎 (RA) 的研究。
三、产品详情
名称:Research Grade Briobacept,科研级Briobacept
货号:DHJ85303
表达系统:Mammalian Cells
种属反应性:Human
同种型:Fusion - [TNFRSF13C (tumor necrosis factor receptor (TNFR) superfamily member 13C, BAFFR, BR3, B cell activating factor receptor, CD268)] 2 - IGHG1 Fc (Fragment constant)
靶标:BAFF, ZTNF4, BLYS, Tumor necrosis factor ligand superfamily member 13B, Dendritic cell-derived TNF-like molecule, TALL-1, TNF- and APOL-related leukocyte expressed ligand 1, BLyS, B lymphocyte stimulator, TNFSF13B, CD257, TNFSF20, TALL1, B-cell-activating factor
浓度:1 mg/ml
内毒素水平:Please contact with the lab for this information.
纯度:>95% as determined by SDS-PAGE.
纯化方式:Protein A/G purified from cell culture supernatant.
Accession 号:Q9Y275
克隆号:Briobacept
应用:Research Grade Biosimilar
状态:Liquid
保存溶液:0.01M PBS, pH 7.4.
稳定性和存储:Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1 - 2 weeks). Store at -20°C 12 months. Store at -80°C long term.
别名:BR3-Fc,SS-79, CAS: 869881-54-9
四、参考文献:
The efficacy of novel B cell biologics as the future of SLE treatment: a review.PMID:25149393
The immunological basis of B-cell therapy in systemic lupus erythematosus.PMID:20374380
[Novel B-cell directed strategies for the treatment of rheumatic diseases].PMID:19513729
Gateways to clinical trials. December 2008.PMID:19271026
Emerging therapeutics for rheumatoid arthritis.PMID:18937634
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