一、中文名称:
Research Grade Anti-Human ROR1 (LCB 71) (DHF90703),ROR1 Anti (LCB 71)蛋白抗体,精品蛋白抗体试剂盒
二、产品描述
ROR1(receptor tyrosine kinase-like orphan receptor 1)是一种I型跨膜蛋白,属于受体酪氨酸激酶样孤儿受体(ROR)家族。ROR1与核受体中的ROR家族不同,ROR是一类膜受体。它们与家族中的原肌球蛋白激酶受体家族(tropomyosin-related kinase, Trk)、骨骼肌特异性酪氧酸激酶样受体家族(muscle specific knase, MuSK)和神经营养因子酯氨酸激酶受体家族(neurotrophic tyrosine kinase receptor, NT-RTK)关系密切,由于ROR蛋白最初发现时配体未知,所以被定义为孤儿受体。现在已知ROR家族成员是Wnt家族信号分子Wnt5a/b和Wnt16的受体,Wnt5a为主要配体。ROR1通过与配体Wnt5a结合,介导非经典Wnt信号通路(non-canonical Wnt pathways)的信号传递。该信号参与多种细胞生理过程和多种癌症的发生和发展。
ROR1是单次跨膜受体,包含细胞外部分、跨膜部分和细胞质区域。
三、产品详情
名称:Research Grade Anti-Human ROR1 (LCB 71) (DHF90703),ROR1 Anti (LCB 71)蛋白抗体,体内中和抗体,活性抗体
货号:DHF90703
表达系统:Mammalian Cells
种属反应性:Human
宿主:Human
同种型:IgG
克隆类型:Monoclonal
靶标:Neurotrophic tyrosine kinase, receptor-related 1, Inactive tyrosine-protein kinase transmembrane receptor ROR1, NTRKR1, ROR1
浓度:1 mg/ml
内毒素水平:Please contact with the lab for this information.
纯度:>95% as determined by SDS - PAGE.
纯化方式:Protein A/G purified from cell culture supernatant.
Accession号:Q01973
克隆号:LCB 71
应用:Research Grade Biosimilar
状态:Liquid
保存溶液:0.01M PBS, pH 7.4.
稳定性和存储:Use a manual defrost freezer and avoid repeated freeze - thaw cycles. Store at 4°C short term (1 - 2 weeks). Store at -20°C 12 months. Store at -80°C long term.
别名:LCB - 71, LCB 71, LCB71
四、参考文献:
Anti-ROR1 CAR-T cells: Architecture and performance. PMID: 36873868
ROR1 targeting with the antibody-drug conjugate VLS-101 is effective in Richter syndrome patient-derived xenograft mouse models. PMID: 33512452
ROR1-STAT3 signaling contributes to ovarian cancer intra-tumor heterogeneity. PMID: 37400436
ROR1, an embryonic protein with an emerging role in cancer biology. PMID: 24752542
The Role of ROR1 in Chemoresistance and EMT in Endometrial Cancer Cells. PMID: 37241228
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