一、中文名称：
Stable Receptor Related Protein (RAP) LRP1 Inhibitor，稳定受体相关蛋白（RAP） LRP1抑制剂
二、产品描述
稳定受体相关蛋白（RAP）是脂蛋白受体相关蛋白1（LRP1）的拮抗剂。在中风后通过静脉注射给予RAP，可显著促进运动功能的恢复，并减少血脑屏障（BBB）的渗漏。RAP在控制血友病患者的出血风险方面也可能具有治疗潜力。这种分子能够以高亲和力与LRP1结合，并且在体外和体内均能抑制LRP1的功能。这表明，新型的RAP可能是一种有用的工具，有助于理解脂蛋白代谢、细胞信号传导、血脑屏障完整性的调节，以及血液凝固和纤维蛋白溶解等过程。
三、产品详情
名称：Stable Receptor Related Protein (RAP) LRP1 Inhibitor，稳定受体相关蛋白（RAP） LRP1抑制剂
货号：YHD89802
种属：Homo sapiens (Human)
预测分子量：42.00 kDa
性质：Recombinant
内毒素水平：Please contact with the lab for this information.
纯度：>90% as determined by SDS-PAGE.
应用：Inhibitor
状态：Lyophilized
保存溶液：Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
重悬：Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输：In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名：Stable Receptor Related Protein (RAP) LRP1 Inhibitor, RAP, LRP1 Inhibitor
四、参考文献：
Lactoferrin stimulates osteoblast differentiation through PKA and p38 pathways independent of lactoferrin's receptor LRP1. PMID: 24877241
Cellular growth inhibition by IGFBP-3 and TGF-beta1 requires LRP-1. PMID: 14597676
Generation of a Potent Low Density Lipoprotein Receptor-related Protein 1 (LRP1) Antagonist by Engineering a Stable Form of the Receptor-associated Protein (RAP) D3 Domain. PMID: 26013822
Midkine and LDL-receptor-related protein 1 contribute to the anchorage-independent cell growth of cancer cells. PMID: 17971413
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