一、中文名称:
Recombinant Human NPR1/NPR-A Protein, C-Fc (EHD14701),利钠肽受体1,精品蛋白抗体试剂盒
二、产品描述
心力衰竭是一种全球范围内严重的健康问题,主要表现为心脏无法有效泵血导致静脉充血,出现肺水肿、胸腔积液、腹水等症状。在心力衰竭的情况下,人体的心肌细胞受到牵拉,会释放心房利钠肽(ANP)、脑利钠肽(BNP) ,作用于利钠肽受体(NPR1)后触发血管舒张来进行自我保护。
增强ANP和BNP介导的信号通路已成为治疗心力衰竭的潜在有效方法。
心房利钠肽NPPA/ANP和脑利钠肽NPPB/BNP的受体,它们是有效的血管活性激素,在心血管稳态中起关键作用。在与配体结合时具有鸟苷酸环化酶活性。
三、产品详情
名称:Recombinant Human NPR1/NPR-A Protein, C-Fc (EHD14701),利钠肽受体1,重组蛋白
货号:EHD14701
表达系统:Mammalian Cells
种属:Homo sapiens (Human)
蛋白长度:Met1 - Glu473
预测分子量:78.55 kDa
性质:Recombinant
内毒素水平:Please contact with the lab for this information.
纯度:>90% as determined by SDS - PAGE.
Accession号:P16066
应用:ELISA, Immunogen, SDS - PAGE, WB, Bioactivity testing in progress
状态:Lyophilized
保存溶液:Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
重悬:Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
运输:In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储:Use a manual defrost freezer and avoid repeated freeze - thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名:Atrial natriuretic peptide receptor 1, 4.6.1.2, Atrial natriuretic peptide receptor type A, ANP - A, ANPR - A, NPR - A, Guanylate cyclase A, GC - A, NPR1, ANPRA
四、参考文献:
Integrative analyses of biomarkers and pathways for heart failure. PMID: 35346191
Atrial and brain natriuretic peptides: Hormones secreted from the heart. PMID: 29859763
Discovery and SAR of a novel series of Natriuretic Peptide Receptor-A (NPR-A) agonists. PMID: 28958620
Augmentation of natriuretic peptide (NP) receptor A and B (NPR-A and NPR-B) and cyclic guanosine monophosphate (cGMP) signalling as a therapeutic strategy in heart failure. PMID: 38032188
详情请咨询Antibodysystem中国授权总代理-武汉佰乐博生物技术有限公司
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