一、中文名称：
Recombinant CRM197 (Nontoxic Diphtheria Toxin)，重组CRM197蛋白，精品蛋白抗体试剂盒
二、产品描述
CRM197是一种将52位的甘氨酸替换为谷氨酸的单一突变的无毒性的白喉毒素突变体，致使白喉毒素酶活性位点发生改变，从而不能对细胞产生毒性作用，但在抗原性和免疫原性上仍和天然白喉毒素保持一致。CRM197是一种研究明确的蛋白质，作为多糖和半抗原的载体使其具有免疫原性。它被用作一种载体蛋白，用于许多已经被批准的疫苗，比如脑膜炎球菌、乙型流感嗜血杆菌和肺炎球菌感染的结合疫苗。
三、产品详情
名称：Recombinant CRM197 (Nontoxic Diphtheria Toxin)，重组CRM197蛋白，体内中和抗体，活性抗体
货号：YXX05401
表达系统：E. coli
种属：Corynephage omega
蛋白长度：Ala25 - Ser560
预测分子量：61 kDa
性质：Recombinant
内毒素水平：Please contact with the lab for this information.
纯度：>90% as determined by SDS - PAGE.
Accession号：P00587
应用：ELISA, Immunogen, SDS - PAGE, WB, Bioactivity testing in progress
状态：Lyophilized
保存溶液：Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
重悬：Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
运输：In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze - thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
别名：Diphtheria toxin, DT, NAD(+)--diphthamide ADP - ribosyltransferase, Diphtheria toxin fragment A, Diphtheria toxin fragment B, CRM197, Nontoxic Diphtheria Toxin
四、参考文献：
Cross reacting material (CRM197) as a carrier protein for carbohydrate conjugate vaccines targeted at bacterial and fungal pathogens.PMID:35872318
Production and purification of an active CRM197 in Pichia pastoris and its immunological characterization using a Vi-typhoid antigen vaccine.PMID:34774362
CRM197-conjugated peptides vaccine of HCMV pp65 and gH induce maturation of DC and effective viral-specific T cell responses.PMID:36723437
CRM197-conjugated multi antigen dominant epitope for effective human cytomegalovirus vaccine development.PMID:36252620
CRM197 reverses paclitaxel resistance by inhibiting the NAC-1/Gadd45 pathway in paclitaxel-resistant ovarian cancer cells.PMID:31490008
Fluorine-modified sialyl-Tn-CRM197 vaccine elicits a robust immune response.PMID:31267246
Synthetic peptide representing a T-cell epitope of CRM197 substitutes as carrier molecule in a Haemophilus influenzae type B (Hib) conjugate vaccine.PMID:2481959
Update on the use of meningococcal serogroup C CRM197-conjugate vaccine (Meningitec) against meningitis.PMID:26560735
Development and clinical evaluation of Prevnar 13, a 13-valent pneumocococcal CRM197 conjugate vaccine.PMID:22830997
Haemophilus b oligosaccharide-CRM197 and other Haemophilus b conjugate vaccines: a status report.PMID:2692432
详情请咨询Antibodysystem中国授权总代理-武汉佰乐博生物技术有限公司
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