一、中文名称：
Anti-Human IL11 Antibody (SAA0379) (FHD42210)，抗人白细胞介素 11 抗体（SAA0379），精品蛋白抗体试剂盒
二、产品描述
白介素11（IL-11,Interleukin-11 or adipogenesis inhibitory factor）是一种促炎性细胞因子，属于IL-6细胞因子家族。细胞因子是细胞分泌的蛋白质或多肽，能够影响细胞间的相互作用和通讯。IL-11在正常情况下参与许多生理过程，包括造血、骨骼发育和免疫反应。然而，随着年龄的增长，IL-11在体内的水平会逐渐上升，尤其是在肝脏、脂肪组织和骨骼肌中。这种上升与许多与衰老相关的病理变化有关，例如代谢紊乱、慢性炎症和细胞衰老。
三、产品详情
名称：Anti-Human IL11 Antibody (SAA0379) (FHD42210)，抗人白细胞介素 11 抗体（SAA0379），体内中和抗体，活性抗体
货号：FHD42210
种属反应性：Human
宿主：Human
同种型：IgG1, kappa
克隆类型：Monoclonal
偶联物：Unconjugated
靶标：Adipogenesis inhibitory factor, AGIF, IL11, IL - 11, Interleukin - 11, Oprelvekin
浓度：1 mg/ml
内毒素水平：Please contact with the lab for this information.
纯度：>95% as determined by SDS - PAGE.
纯化方式：Protein A/G purified from cell culture supernatant.
Accession号：P20809
克隆号：SAA0379
应用：ELISA, FCM
状态：Liquid
保存溶液：0.01M PBS, pH 7.4, 0.09% Sodium azide.
稳定性和存储：Use a manual defrost freezer and avoid repeated freeze - thaw cycles. Store at 4°C short term (1 - 2 weeks). Store at -20°C 12 months. Store at -80°C long term.
四、参考文献：
Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge.PMID:35731866
Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease.PMID:36470928
IL11 activates the placental inflammasome to drive preeclampsia.PMID:37292200
IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFbeta.PMID:38455057
Cardiomyocyte-Restricted Expression of IL11 Causes Cardiac Fibrosis, Inflammation, and Dysfunction.PMID:37629170
IL11 Stimulates IL33 Expression and Proinflammatory Fibroblast Activation across Tissues.PMID:36012165
Pharmacologic inhibition of IL11/STAT3 signaling increases MHC-I expression and T cell infiltration.PMID:37365574
Understanding interleukin 11 as a disease gene and therapeutic target.PMID:38054591
IL11 signaling mediates piR-2158 suppression of cell stemness and angiogenesis in breast cancer.PMID:37153732
Inhibition of IL-11 signalling extends mammalian healthspan and lifespan.PMID:39020175
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