介绍：DNA-RNA杂交种是真核细胞中的自然现象，这些杂交体的水平在具有高转录活性的位点增加，例如在转录起始、抑制和延伸期间。由于RNA-DNA杂交体会影响基因组的不稳定性，因此S9.6抗体是一种有用的试剂，有助于研究这些杂交体在DNA复制或其他细胞过程中形成的R环和病变的后果。S9.6抗体可有效识别用于微阵列研究的RNA-DNA杂交。
佰乐博生物：佰乐博生物代理Antibodysystem品牌，是亚洲区运营总代理商
链接：https://www.antibodysystem.com/product/7992.html
名称：Anti-DNA-RNA Hybrid Antibody(S9.6)单克隆抗体
别名：DNA-RNA Hybrid，clone S9.6，S9.6单克隆抗体
货号：RGK60001
宿主：Mouse
适用物种：General
应用：CHIP, ChIP-seq, DB, EMSA, FISH, ICC, IP, SPR, IF
形式：Liquid
纯度：>95%
克隆：Monoclonal
同型：IgG2a, kappa
内毒素水平：Please contact with the lab for this information.
表达系统：Mammalian cells
用途范围：仅用于科研
储存：Use a manual defrost freezer and avoid repeated freeze-thaw cycles.Store at +4°C short term (1-2 weeks).Store at -20 °C 12 months. Store at -80°C long term.
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咨询邮箱：products@biolabreagent.com
选购商城：https://www.antibodysystem.com
微信公众平台：佰乐博生物Biolab Reagents
参考文献：
Recognition of RNA by the S9.6 antibody creates pervasive artifacts when imaging RNA:DNA hybrids. PMID: 33830170
Detection of R-Loop Structures by Immunofluorescence Using the S9.6 Monoclonal Antibody. PMID: 35704182
High-resolution, strand-specific R-loop mapping via S9.6-based DNA-RNA immunoprecipitation and high-throughput sequencing. PMID: 31053798
S9.6 Antibody-Enzyme Conjugates for the Detection of DNA-RNA Hybrids. PMID: 37194248
S9.6-based hybrid capture immunoassay for pathogen detection. PMID: 38110611
R-Loop Analysis by Dot-Blot. PMID: 33554969
RNA/DNA Hybrid Interactome Identifies DXH9 as a Molecular Player in Transcriptional Termination and R-Loop-Associated DNA Damage. PMID: 29742442
Structural basis of R-loop recognition by the S9.6 monoclonal antibody. PMID: 35347133
Immunoprecipitation of DNA:RNA Hybrids Using the S9.6 Antibody. PMID: 32681514
Catalytically inactive, purified RNase H1: A specific and sensitive probe for RNA-DNA hybrid imaging. PMID: 34232287
Mapping R-Loops and RNA:DNA Hybrids with S9.6-Based Immunoprecipitation Methods. PMID: 34515688
Cryo-EM structure of R-loop monoclonal antibody S9.6 in recognizing RNA:DNA hybrids. PMID: 35550870
Modifications and interactions at the R-loop. PMID: 32961406
The monoclonal S9.6 antibody exhibits highly variable binding affinities towards different R-loop sequences. PMID: 28594954
R-Loop Detection in Bacteria. PMID: 35704183
Approaches for Mapping and Analysis of R-loops. PMID: 38666626
New insight into the biology of R-loops. PMID: 32516653
Quantitative DNA-RNA Immunoprecipitation Sequencing with Spike-Ins. PMID: 35704206
The Affinity of the S9.6 Antibody for Double-Stranded RNAs Impacts the Accurate Mapping of R-Loops in Fission Yeast. PMID: 29289567
Genome-wide map of R-loops reveals its interplay with transcription and genome integrity during germ cell meiosis. PMID: 36396044
The sub-nanomolar binding of DNA-RNA hybrids by the single-chain Fv fragment of antibody S9.6. PMID: 23784994
A rapid and simple method for simultaneous determination of three breast cancer related microRNAs based on magnetic nanoparticles modified with S9.6 antibody. PMID: 36682580
Detection of TERRA R-Loops at Human Telomeres. PMID: 35704191
DNA-RNA Hybrids at Telomeres in Budding Yeast. PMID: 35704190
Best practices for the visualization, mapping, and manipulation of R-loops. PMID: 33411340
Immunofluorescence microscopy of G-quadruplexes and R-loops. PMID: 38521582
Strengths and Weaknesses of the Current Strategies to Map and Characterize R-Loops. PMID: 29657305
Topology of RNA:DNA Hybrids and R-Loops in Yeast. PMID: 35704201
Detection of DNA-RNA Hybrids In Vivo. PMID: 29043635
