|

| 产地 | France |
| 品牌 | AntibodySystem |
| 货号 | YHE20001 |
| 用途 | 仅用于科研 |
| 包装规格 | 100 μg |
| 纯度 | 0.95% |
| CAS编号 | |
| 是否进口 | 否 |
| 货号 | YHE20001 |
| 产品名称 | Recombinant Human SREBF1/SREBP1 Protein, N-His |
| 规格 | 100 μg |
| 价格 | 1880 |
| 状态 | Lyophilized |
| 储存缓冲液 | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 0.02% SKL, 5% Trehalose, 2% Mannitol. |
| 纯度 | >90% as determined by SDS-PAGE. |
| 应用 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 内毒水平 | Please contact with the lab for this information. |
| 表达系统 | E. coli |
| Accession | P36956 |
| 蛋白长度 | Glu30-Leu490 |
| 预测分子量 | 49.80 kDa |
| 稳定性与储存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 重悬 | Reconstitute in sterile water for a stock solution. |
| 别名 | Sterol regulatory element-binding protein 1, SREBF1, BHLHD1, Transcription factor SREBF1, Sterol regulatory element-binding transcription factor 1, Class D basic helix-loop-helix protein 1, bHLHd1, SREBP-1, SREBP1 |
| 物种 | Homo sapiens (Human) |
| 运输 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 备注 | For research use only. |
SREBF1(固醇调节元件结合蛋白1)属于核转录因子,主导脂质合成相关基因转录,调控脂肪酸与甘油三酯生成,广泛存在于多种组织细胞。表达失衡会打破脂质代谢平衡,是脂代谢调控、细胞脂质稳态方向常用研究靶点。
前沿相关研究:
1.Mammalian lipophagy: process and function. Autophagy. PMID: 41681129.
2.Autophagy sustains mitochondrial respiration and determines resistance to BRAFV600E inhibition in thyroid carcinoma cells. PMID: 38436206.
3.Limiting cap-dependent translation increases 20S proteasomal degradation and protects the proteomic integrity in autophagy-deficient skeletal muscle. PMID: 39878121.