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| 产地 | France |
| 品牌 | AntibodySystem |
| 货号 | YHE11001 |
| 用途 | 仅用于科研 |
| 包装规格 | 100 μg |
| 纯度 | 0.95% |
| CAS编号 | |
| 是否进口 | 否 |
| 货号 | YHE11001 |
| 产品名称 | Recombinant Human THBS4 Protein, N-GST |
| 规格 | 100 μg |
| 价格 | 1880 |
| 状态 | Lyophilized |
| 储存缓冲液 | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 纯度 | >90% as determined by SDS-PAGE. |
| 应用 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 内毒水平 | Please contact with the lab for this information. |
| 表达系统 | E. coli |
| Accession | P35443 |
| 蛋白长度 | Pro644-Leu866 |
| 预测分子量 | 51.38 kDa |
| 稳定性与储存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 重悬 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 别名 | THBS4, Thrombospondin-4, TSP4 |
| 物种 | Homo sapiens (Human) |
| 运输 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 备注 | For research use only. |
THBS4(血小板反应蛋白4)属于基质钙结合糖蛋白,介导细胞与胞外基质相互作用,调控脉管新生、组织重塑与细胞存活,心肌、平滑肌均可分泌。蛋白表达紊乱会破坏脉管与组织结构稳态,是胞外基质重构、脉管新生调控方向常用研究靶点。
Q1:重组人 THBS4 蛋白纯度多少?
A:经 SDS-PAGE 检测纯度>90%,可满足常规科研实验使用。
Q2:THBS4 蛋白怎么配制储备液?
A:无菌纯水复溶制备储备液,详细步骤查阅随货说明书。
Q3:储存方式与保质期?
A:频繁取用 2~8℃存放;长期 - 20~-80℃保存,收货有效期 12 个月。选用手动除霜冰箱,杜绝反复冻融,防止蛋白失活。
Q4:蛋白适用实验场景?
A:可开展 ELISA、免疫原制备、SDS-PAGE、WB 实验,生物活性验证测试中,仅用于科研使用。
前沿相关研究:
1.Fibroblast-specific TGF-β signaling mediates cardiac dysfunction, fibrosis, and hypertrophy in obese diabetic mice. PMID: 39373248.
2.Complement C3a treatment accelerates recovery after stroke via modulation of astrocyte reactivity and cortical connectivity. PMID: 36995772.
3.The Role of THBS4 in Chronic Kidney Disease Fibrosis: From Clinical Observations to Molecular Mechanisms.PMID: 40765330.
4.Analysis of joint protein expression profile in anterior disc displacement of TMJ with or without OA. PMID:38251222.
5.THBS4 downregulation alters trophoblast function in preeclampsia via the TGF-β1/Smad signaling cascade.PMID: 40478535.
6.THBS4 Regulates Pulmonary Hypertension via TGF-β/SMAD2 Signaling. Hypertension. PMID: 41873540.
7.Descendants of hypertrophic chondrocytes promote angiogenesis by secreting THBS4 during bone growth and injury repair. PMID: 41207902.