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| 产地 | France |
| 品牌 | AntibodySystem |
| 货号 | YHE10901 |
| 用途 | 仅用于科研 |
| 包装规格 | 100 μg |
| 纯度 | 0.95% |
| CAS编号 | |
| 是否进口 | 否 |
| 货号 | YHE10901 |
| 产品名称 | Recombinant Human THBS2 Protein, N-His |
| 规格 | 100 μg |
| 价格 | 1880 |
| 状态 | Lyophilized |
| 储存缓冲液 | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 纯度 | >90% as determined by SDS-PAGE. |
| 应用 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 内毒水平 | Please contact with the lab for this information. |
| 表达系统 | E. coli |
| Accession | P35442 |
| 蛋白长度 | Asp968-Ile1172 |
| 预测分子量 | 25.81 kDa |
| 稳定性与储存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 重悬 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 别名 | Thrombospondin-2, TSP2, THBS2 |
| 物种 | Homo sapiens (Human) |
| 运输 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 备注 | For research use only. |
THBS2(血小板反应蛋白2)属于凝血酶敏感蛋白家族,是胞外基质分泌蛋白。参与细胞黏附、胞间信号传导以及基质重塑过程,在多种组织中表达。蛋白表达失衡会干扰微环境稳态,是细胞基质相关机制研究的重要靶点。
Q1:这款重组人 THBS2 蛋白的纯度是多少?
A:本产品经 SDS-PAGE 检测,纯度大于 90%,可满足各类常规科研实验需求。
Q2:该 THBS2 蛋白如何复溶配制储备液?
A:可直接使用无菌水复溶配制储备液,详细标准化复溶操作步骤可查阅产品配套说明书。
Q3:这款重组 THBS2 蛋白的储存条件与保质期是什么?
A:日常频繁使用可保存于 2~8℃;长期保存需置于 - 20~-80℃环境,自收货之日起保质期 12 个月。储存需使用手动除霜冰箱,避免反复冻融,防止蛋白活性流失。
Q4:该重组人 THBS2 蛋白可应用于哪些实验?
A:产品适用于 ELISA、免疫原制备、SDS-PAGE、WB 等实验,目前生物活性检测正在推进中,仅可用于科研用途。
前沿相关研究:
1. THBS2-producing matrix CAFs promote colorectal cancer progression and link to poor prognosis via the CD47-MAPK axis. Cell Rep. PMID: 40222008.
2.Cancer-associated fibroblasts drive lung adenocarcinoma progression via THBS2-mediated epithelial-mesenchymal transition. PMID: 40973793.
3.Enhanced THBS2 promotes collagen synthesis and inflammatory secretome of fibroblasts in idiopathic pulmonary fibrosis. PMID: 40676074.
4.Targeting fibroblast derived thrombospondin 2 disrupts an immune-exclusionary environment at the tumor front in colorectal cancer. PMID:41276505.
5.Integrative multi-omics and Mendelian randomization identify WWOX and THBS2 as potential therapeutic targets in mature T/NK-cell lymphoma. PMID: 41254692.
6.Exosomal ALPPL2 and THBS2 as biomarkers for early detection and disease monitoring of pancreatic ductal adenocarcinoma.PMID:40897818.
7.Mapping the Proteomic Landscape of Pancreatic Cancer: Prognostic Insights and Subtype Stratification.PMID:41003647.