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| 产地 | France |
| 品牌 | AntibodySystem |
| 货号 | YHD99501 |
| 用途 | 仅用于科研 |
| 包装规格 | 100 μg |
| 纯度 | 0.95% |
| CAS编号 | |
| 是否进口 | 否 |
| 货号 | YHD99501 |
| 产品名称 | Recombinant Human CD197/CCR7 Protein, N-His |
| 规格 | 100 μg |
| 价格 | 1880 |
| 状态 | Lyophilized |
| 储存缓冲液 | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 2% Mannitol |
| 纯度 | >90% as determined by SDS-PAGE. |
| 应用 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 内毒水平 | Please contact with the lab for this information. |
| 表达系统 | E. coli |
| Accession | P32248 |
| 蛋白长度 | Asn290-Pro378 |
| 预测分子量 | 12.54 kDa |
| 稳定性与储存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 重悬 | Reconstitute in sterile water for a stock solution. |
| 别名 | CDw197, EVI1, CMKBR7, CCR7, C-C CKR-7, CD197, CCR-7, Epstein-Barr virus-induced G-protein coupled receptor 1, MIP-3 beta receptor, EBI1, CC-CKR-7, BLR2, EBV-induced G-protein coupled receptor 1, C-C chemokine receptor type 7 |
| 物种 | Homo sapiens (Human) |
| 运输 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 备注 | For research use only. |
CD197/CCR7 为趋化因子受体,介导免疫细胞定向迁移归巢,调控淋巴细胞转运与外周免疫组织构建,免疫细胞广泛表达。表达紊乱会扰乱免疫细胞分布平衡,是细胞趋化、免疫微环境构建方向常用研究靶点。
前沿相关研究:
1.Reblastatins Inhibit Phenotypic Changes of Monocytes/Macrophages in a Milieu Rich in 27-Hydroxycholesterol., PMID:32395369
2.Third-generation anti-CD19 CAR T cells for relapsed/refractory chronic lymphocytic leukemia: a phase 1/2 study., PMID:39192036
3.Dysregulated T helper type 1 (Th1) and Th17 responses in elderly hospitalised patients with infection and sepsis., PMID:31658288
4.Assessing the immunopotency of Toll-like receptor agonists in an in vitro tissue-engineered immunological model., PMID:20331478
5.The intestinal archaea Methanosphaera stadtmanae and Methanobrevibacter smithii activate human dendritic cells., PMID:24915454
6.Erythropoietin exerts direct immunomodulatory effects on the cytokine production by activated human T-lymphocytes., PMID:27208431
7.Saccharomyces boulardii inhibits lipopolysaccharide-induced activation of human dendritic cells and T cell proliferation., PMID:19161443