|

| 产地 | France |
| 品牌 | AntibodySystem |
| 货号 | YHD47801 |
| 用途 | 仅用于科研 |
| 包装规格 | 100 μg |
| 纯度 | 0.95% |
| CAS编号 | |
| 是否进口 | 否 |
| 货号 | YHD47801 |
| 产品名称 | Recombinant Human VDAC1 Protein, N-His |
| 规格 | 100 μg |
| 价格 | 1880 |
| 状态 | Lyophilized |
| 储存缓冲液 | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 2% Mannitol |
| 纯度 | >90% as determined by SDS-PAGE. |
| 应用 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 内毒水平 | Please contact with the lab for this information. |
| 表达系统 | E. coli |
| Accession | P21796 |
| 蛋白长度 | Met1-Ala283 |
| 预测分子量 | 33.08 kDa |
| 稳定性与储存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 重悬 | Reconstitute in sterile water for a stock solution. |
| 别名 | Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, hVDAC1, Porin 31HL, Porin 31HM, Voltage-dependent anion-selective channel protein 1, VDAC1, VDAC-1, VDAC |
| 物种 | Homo sapiens (Human) |
| 运输 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 备注 | For research use only. |
背景介绍:
VDAC1(电压依赖性阴离子通道蛋白1)主要定位于线粒体外膜,介导离子与小分子物质跨膜转运,调控胞内物质交换与信号传递。该蛋白广泛表达于各类组织,功能波动会影响线粒体稳态,是线粒体生理相关研究的重要靶点。
前沿相关研究:
1.Selection and identification of DNA aptamer binding VDAC1 for tumor tissue imaging and targeted drug delivery., PMID:39984095
2.CREB1 controls mitochondrial dysfunction in 1-nitropyrene-mediated apoptosis of human bronchial cells and lung injury., PMID:39986035
3.Dihydromyricetin regulates the miR-155-5p/SIRT1/VDAC1 pathway to promote liver regeneration and improve alcohol-induced liver injury., PMID:39986231
4.Citrinin-Induced Intestinal Onset of Pyroptosis via the IP3R1-GRP75-VDAC1 Complex-Mediated Mitochondrial Oxidative Stress., PMID:40000072
5.Oxidative stress regulates the catalytic activity and mitochondrial localization of HK2 in trophoblast by regulating K346 lactylation., PMID:40019223
6.Astragalin actives autophagy and inhibits apoptosis of astrocytes in AD mice via down-regulating Fas/Fasl-VDAC1 pathway., PMID:40032030
7.Helium cold atmospheric pressure plasma reduces erastin induced inflammation and ferroptosis in human gingival fibroblasts., PMID:40032893