|

| 产地 | France |
| 品牌 | AntibodySystem |
| 货号 | YHC36901 |
| 用途 | 仅用于科研 |
| 包装规格 | 100 μg |
| 纯度 | 0.95% |
| CAS编号 | |
| 是否进口 | 否 |
| 货号 | YHC36901 |
| 产品名称 | Recombinant Human CD126/IL6R/IL-6RA Protein, N-His |
| 规格 | 100 μg |
| 价格 | 1880 |
| 状态 | Lyophilized |
| 储存缓冲液 | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 纯度 | >90% as determined by SDS-PAGE. |
| 应用 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 内毒水平 | Please contact with the lab for this information. |
| 表达系统 | E. coli |
| Accession | P08887 |
| 蛋白长度 | Gly33-Thr313 |
| 预测分子量 | 33.76 kDa |
| 稳定性与储存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 重悬 | Reconstitute in sterile water for a stock solution. |
| 别名 | sIL6R, Interleukin-6 receptor subunit alpha, CD126, IL-6R 1, IL-6R subunit alpha, Membrane glycoprotein 80, gp80, IL6R, IL-6RA, IL-6 receptor subunit alpha, IL-6R-alpha |
| 物种 | Homo sapiens (Human) |
| 运输 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 备注 | For research use only. |
CD126/IL6R为白介素6受体亚基,结合配体启动胞内信号,调控细胞增殖、免疫应答,免疫细胞与上皮细胞高表达。表达失衡会打乱免疫调控机制,是免疫信号通路、细胞增殖调控常用研究靶点。
Q1:CD126/IL6R 蛋白基础生产参数?
A:大肠杆菌表达搭配 N 端 His 标签,理论分子量 33.76 kDa,电泳纯度大于 90%。
Q2:冻干蛋白复溶操作方法?
A:无菌纯水溶解制备储备液,详细操作流程可参考配套说明书。
Q3:保存方式以及保质时长?
A:日常取用置于 2~8℃环境,长期分装存放于 - 20~-80℃,有效期 12 个月,避免反复冻融。
Q4:适用实验类型以及使用范围?
A:可开展 WB、ELISA、免疫原制备实验,活性正在检测,仅用于科研场景使用。
前沿相关研究:
1.Neutrophil Z Is a Novel Marker to Differentiate Disease Flares From Bacterial Infections in Febrile SLE Patients., PMID:40302194
2.Escherichia coli aggravates inflammatory response in mice oral mucositis through regulating Th17/Treg imbalance., PMID:40365536
3.Impact of resistance training on inflammatory biomarkers and associations with treatment outcomes in colon cancer., PMID:40278841
4.Polymorphisms in rs2069845 are associated with IL-6 and soluble IL-6 receptor levels during total joint replacement., PMID:40373041
5.Vitamin D inhibits apoptosis in THP-1 cells infected with mycobacterium tuberculosis through TNF signaling pathway., PMID:40396181
6.Study of some biological markers in cord blood of preterm and term infants and their association with neonatal sepsis., PMID:40353384
7.Highly elevated sepsis biomarkers in advanced cholangiocarcinoma without sepsis: A case report and literature review., PMID:40419900