货号	YHC20201
产品名称	Recombinant Human CDK1 Protein, N-His
规格	100 μg
价格	1880
状态	Lyophilized
储存缓冲液	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
纯度	>90% as determined by SDS-PAGE.
应用	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
内毒水平	Please contact with the lab for this information.
表达系统	E. coli
Accession	P06493
蛋白长度	Met1-Met297
预测分子量	36.41 kDa
稳定性与储存条件	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
重悬	Reconstitute in sterile water for a stock solution.
别名	CDC28A, CDKN1, P34CDC2, p34 protein kinase, CDK1, Cell division protein kinase 1, Cell division control protein 2 homolog, CDC2, Cyclin-dependent kinase 1
物种	Homo sapiens (Human)
运输	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
备注	For research use only.

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背景介绍：

CDK1（周期蛋白依赖性激酶1），细胞周期核心调控蛋白，结合周期蛋白后激活，驱动细胞完成分裂进程，把控细胞增殖周期运转。广泛存在于增殖活跃的细胞中，蛋白功能紊乱会造成细胞周期运转失常，是细胞增殖、周期调控方向的经典研究靶点。

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前沿相关研究：

1.Naphthalimide derivative attenuates tumor growth of wild-type p53-expressing U87 glioma cells in vitro and in vivo through a biphasic dose-dependent mechanism: A switch from cell cycle to apoptosis., PMID:40294493

2.Identification and validation of programmed cell death related biomarkers for the treatment and prevention COVID-19., PMID:40300201

3.IGF2BP3 recruits NUDT21 to regulate SPTBN1 alternative polyadenylation and drive ovarian cancer progression., PMID:40301554

4.SNRPB2: a prognostic biomarker and oncogenic driver in esophageal cancer via β-catenin/c-Myc signaling., PMID:40303992

5.Membrane-anchored tissue inhibitor of matrix metalloproteinase (TIMP)-1 promotes cell death in head and neck cancer by inducing DNA damage, accumulating collagen II and disrupting cell survival mechanisms., PMID:40306502

6.Cell cycle duration determines oncogenic transformation capacity., PMID:40307557

7.Identification and validation of susceptibility modules and hub genes of adrenocortical carcinoma through WGCNA and machine learning., PMID:40317315

8.Therapy-induced senescence of glioblastoma cells is determined by the p21CIP1-CDK1/2 axis and does not require activation of DREAM., PMID:40319068

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AntibodySystem于2019年创立于法国，专注于生命科学研究领域蛋白、抗体及试剂盒的研发与生产。致力于为 生命科学基础研究者提供高质量的科研试剂产品。
【核心产品线】 核心产品囊括：病毒/细菌相关抗体&蛋白、In Vivo功能性抗体、低背景流式抗体、高特异性纳米抗体、活性蛋白、PK/ADA试剂盒、特色小分子抗体、DNA/RNA抗体、传统多抗、经典内参及标签抗体。
【应用领域】 目前，旗下产品已全面覆盖热门病毒与超级细菌、寄生虫、tumor相关研究、认知衰退类神经退行性疾病（阿尔茨海默症）、神经组织衰老与神经元功能紊乱相关模型、变态反应与超敏应答、免疫负调控与免疫激活等多个关键科研领域。
【产品优势】 高纯度、高特异性、高灵敏度重组蛋白、抗体以及ELISA 试剂盒。覆盖HRP、Biotin、FITC、PE、APC、PerCP等多种标记类型；适用于Human、Mouse、Rat、Rabbit、Goat等多个种属。 经WB、ELISA、IHC、IF、IP、FCM等多种实验验证，具有优异的特异性、灵敏度和批间一致性。产品常备现货，支持快速交付，并提供详实验证数据及高分文献支持，为tumor相关研究、免疫学、细胞生物学及药物研发提供可靠研究工具。
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