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| 产地 | France |
| 品牌 | AntibodySystem |
| 货号 | EHC15802 |
| 用途 | 仅用于科研 |
| 包装规格 | 100 μg |
| 纯度 | 0.95% |
| CAS编号 | |
| 是否进口 | 否 |
| 货号 | EHC15802 |
| 产品名称 | Recombinant Human IL6 Protein, C-His |
| 规格 | 100 μg |
| 价格 | 2880 |
| 状态 | Lyophilized |
| 储存缓冲液 | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 纯度 | >90% as determined by SDS-PAGE. |
| 应用 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 内毒水平 | Please contact with the lab for this information. |
| 表达系统 | Mammalian Cells |
| Accession | P05231 |
| 蛋白长度 | Val30-Met212 |
| 预测分子量 | 16.74 kDa |
| 稳定性与储存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 重悬 | Reconstitute in sterile water for a stock solution. |
| 别名 | Hybridoma growth factor, BSF-2, IFN-beta-2, CDF, IL6, Interleukin-6, IL-6, B-cell stimulatory factor 2, Interferon beta-2, IFNB2, CTL differentiation factor |
| 物种 | Homo sapiens (Human) |
| 运输 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 备注 | For research use only. |
IL6(白介素6)是多功能分泌型细胞因子,能够激活多条胞内信号通路,参与免疫调控、组织修复与物质代谢调节。在多种体细胞中均可合成释放,表达异常易打破机体稳态,是免疫调控、组织修复相关研究的热门靶点。
Q1:这款重组人 IL6 蛋白纯度是多少?
A:经 SDS-PAGE 检测纯度>90%,适配各类常规科研实验。
Q2:IL6 蛋白如何复溶配制储备液?
A:采用无菌水溶解即可配制储备液,详细操作可查阅随货说明书。
Q3:储存条件与保质期?
A:频繁使用可置于 2~8℃保存;长期存放于 - 20~-80℃环境,收货后保质期 12 个月。选用手动除霜冰箱储存,避免反复冻融导致蛋白活性下降。
Q4:重组人 IL6 蛋白可用于哪些实验?
A:适用于 ELISA、免疫原制备、SDS-PAGE、WB 实验,生物活性检测正在开展,仅用于科研用途。
前沿相关研究:
1.Interleukin-6, Tocilizumab and Atherosclerosis. Comment on Gerasimova et al. Interleukin-6: Cardiovascular Aspects of Long-Term Cytokine Suppression in Patients with Rheumatoid Arthritis. Int. J. Mol. Sci. 2024, 25, 12425., PMID:40243553
2.Reply to Saleh, C.; Budincevic, H. Interleukin-6, Tocilizumab and Atherosclerosis. Comment on "Gerasimova et al. Interleukin-6: Cardiovascular Aspects of Long-Term Cytokine Suppression in Patients with Rheumatoid Arthritis. Int. J. Mol. Sci. 2024, 25, 12425"., PMID:40243555
3.Salivary Interleukin-6 and Interleukin-18 Levels and Their Association with Dental Health in Children with Idiopathic Nephrotic Syndrome., PMID:40243946
4.Human IL-6-Producing B Cells Promote the Differentiation of Monocytes Toward an Anti-Inflammatory CD16⁺CD163⁺CD206⁺PD-L1⁺ Phenotype in Tuberculosis., PMID:40252014
5.Role of IL-2, IL-6, and TNF-α as Potential Biomarkers in Ischemic Heart Disease: A Comparative Study of Patients with CAD and Non-CAD., PMID:40265387
6.Investigating the relationship between the IL-17 rs2275913, IL-17 rs763780, and the IL-6 rs1800795 genotypes in HIV-positive patients with COVID-19., PMID:40268781
7.The interplay between cell-free DNA, hepcidin, and interleukin-6 in chronic kidney disease induced inflammation and progression to a hemodialysis dependent state., PMID:40272917