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| 产地 | France |
| 品牌 | AntibodySystem |
| 货号 | YHB86001 |
| 用途 | 仅用于科研 |
| 包装规格 | 100 μg |
| 纯度 | 0.95% |
| CAS编号 | |
| 是否进口 | 否 |
| 货号 | YHB86001 |
| 产品名称 | Recombinant Human SOD1 Protein, N-His |
| 规格 | 100 μg |
| 价格 | 1880 |
| 状态 | Lyophilized |
| 储存缓冲液 | Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| 纯度 | >90% as determined by SDS-PAGE. |
| 应用 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 内毒水平 | Please contact with the lab for this information. |
| 表达系统 | E. coli |
| Accession | P00441 |
| 蛋白长度 | Met1-Gln154 |
| 预测分子量 | 18.25 kDa |
| 稳定性与储存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 重悬 | Reconstitute in sterile water for a stock solution. |
| 别名 | Superoxide dismutase [Cu-Zn], SOD1, hSod1, Superoxide dismutase 1 |
| 物种 | Homo sapiens (Human) |
| 运输 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 备注 | For research use only. |
背景介绍:
SOD1(超氧化物歧化酶1),抗氧化功能蛋白,清除胞内活性氧自由基,抵御氧化损伤,各组织细胞广泛表达。表达异常易引发氧化代谢失衡,是抗氧化机制、细胞氧化稳态调控常用研究靶点。
前沿相关研究:
1.SOD1, A Crucial Protein for Neural Biochemistry: Dysfunction and Risk of Amyotrophic Lateral Sclerosis. PMID: 40419749.
2.Long-Term Tofersen in SOD1 Amyotrophic Lateral Sclerosis. JAMA Neurol.PMID: 41661214.
3.Tofersen for SOD1 amyotrophic lateral sclerosis: a systematic review and meta-analysis. PMID: 39820998.
4.Tofersen: A Review in Amyotrophic Lateral Sclerosis Associated with SOD1 Mutations. PMID: 40640528.
5.Amyotrophic lateral sclerosis caused by SOD1 variants: from genetic discovery to disease prevention. PMID: 39706636.
6.Amyotrophic Lateral Sclerosis: A Review. JAMA. PMID: 42113599.
7.RNAi-mediated silencing of SOD1 profoundly extends survival and functional outcomes in ALS mice. Mol Ther. PMID: 40349108.