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| 产地 | France |
| 品牌 | AntibodySystem |
| 货号 | YHB14401 |
| 用途 | 仅用于科研 |
| 包装规格 | 100 μg |
| 纯度 | 0.95% |
| CAS编号 | |
| 是否进口 | 否 |
| 货号 | YHB14401 |
| 产品名称 | Recombinant Human DUSP11 Protein, N-His |
| 规格 | 100 μg |
| 价格 | 1880 |
| 状态 | Lyophilized |
| 储存缓冲液 | Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 2% Mannitol |
| 纯度 | >90% as determined by SDS-PAGE. |
| 应用 | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 内毒水平 | Please contact with the lab for this information. |
| 表达系统 | E. coli |
| Accession | O75319 |
| 蛋白长度 | Gly75-Trp255 |
| 预测分子量 | 23.60 kDa |
| 稳定性与储存条件 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 重悬 | Reconstitute in sterile water for a stock solution. |
| 别名 | Phosphatase that interacts with RNA/RNP complex 1, Dual specificity protein phosphatase 11, DUSP11, RNA/RNP complex-1-interacting phosphatase, PIR1 |
| 物种 | Homo sapiens (Human) |
| 运输 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 备注 | For research use only. |
DUSP11(双特异性磷酸酶 11,又称 PIR1)属于非常规双特异性磷酸酶,兼具 RNA 磷酸酶活性,参与非编码 RNA 代谢、阻滞炎性信号传导,调控细胞增殖进程,广泛表达于多种组织细胞。表达失衡会扰乱核酸稳态与免疫应答,是 RNA 代谢调控、炎性信号通路研究常用靶点。
前沿相关研究:
1.The SUMO-targeted ubiquitin ligase, Dgrn, is essential for Drosophila innate immunity., PMID:28621429
2.PIR1, a novel phosphatase that exhibits high affinity to RNA . ribonucleoprotein complexes., PMID:9685386
3.DUSP11 Attenuates Lipopolysaccharide-Induced Macrophage Activation by Targeting TAK1., PMID:32796023
4.RNA triphosphatase DUSP11 enables exonuclease XRN-mediated restriction of hepatitis C virus., PMID:30038017
5.DUSP11 - An RNA phosphatase that regulates host and viral non-coding RNAs in mammalian cells., PMID:28296624
6.RIG-I like receptor sensing of host RNAs facilitates the cell-intrinsic immune response to KSHV infection., PMID:30451863