货号	YHA68101
产品名称	Recombinant Human KLF4 Protein, N-His
规格	100 μg
价格	1880
状态	Lyophilized
储存缓冲液	Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
纯度	>90% as determined by SDS-PAGE.
应用	ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
内毒水平	Please contact with the lab for this information.
表达系统	E. coli
Accession	O43474
蛋白长度	Leu352-Phe513
预测分子量	21.01 kDa
稳定性与储存条件	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
重悬	Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
别名	KLF4, Gut-enriched krueppel-like factor, Krueppel-like factor 4, EZF, GKLF, Epithelial zinc finger protein EZF
物种	Homo sapiens (Human)
运输	In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
备注	For research use only.

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背景介绍：

KLF4（Kruppel 样因子 4）属于转录因子，参与调控细胞增殖、分化与上皮稳态维持，多种组织细胞均可表达。表达失衡会扰乱细胞生长状态，是细胞分化调控、上皮生理稳态方向常用研究靶点。

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前沿相关研究：

1.The protective effect of iron isomaltoside on myocardial ischemia-reperfusion injury via the suppression of KLF4/NF-κB signaling., PMID:40471885

2.Induction of T-Cell Differentiation by KLF4 in T-Cell Acute Lymphoblastic Leukemia Cells Harboring Activating Mutation in NOTCH3., PMID:40354086

3.Lactylation-boosted polycomb repression of KLF4 elicits glycolysis in retinoblastoma: A positive feedback circuit between histone modifications., PMID:40383410

4.Generation of the induced pluripotent stem cell line LEIi023-A from a rod-cone dystrophy patient carrying the dominant PRPF31 c.267del variant., PMID:40220513

5.Integrative DNA methylome and transcriptome analysis identify potential genes on the influence of dilated cardiomyopathy-associated heart failure., PMID:40296161

6.Efficient Fabrication of Human Corneal Stromal Cell Spheroids and Promoting Cell Stemness Based on 3D-Printed Derived PDMS Microwell Platform., PMID:40149974

7.Wisent Somatic Cells Resist Reprogramming by the PiggyBac Transposon System: A Case Study Highlighting Methodological and Conservation Hurdles., PMID:40362564

8.Glomerular mesangial cells derived complement factor H regulates complement activation, influences cell proliferation, and maintains actin cytoskeleton., PMID:40157080

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AntibodySystem于2019年创立于法国，专注于生命科学研究领域蛋白、抗体及试剂盒的研发与生产。致力于为 生命科学基础研究者提供高质量的科研试剂产品。
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