抗IL-1β多克隆抗体 · 兔源 · 抗原亲和纯化
| 序号 | 您的研究方向 / 需求 | 本产品可直接应用 |
|---|---|---|
| 1 | IL-1β蛋白表达水平的定量检测 | 已验证ELISA应用,推荐稀释比1:4000-1:8000 |
| 2 | 组织切片中IL-1β的定位与分布分析 | 已验证IHC应用,推荐稀释比1:50-1:200 |
| 3 | 细胞中IL-1β的免疫荧光定位 | 已验证IF应用,推荐稀释比1:50-1:200 |
| 4 | 细胞裂解液中IL-1β的蛋白免疫印迹检测 | 已验证WB应用,推荐稀释比1:1000-1:4000 |
白细胞介素-1β(Interleukin-1 beta, IL-1β) 是 IL-1家族 的重要成员,是一种 强效促炎细胞因子,主要由活化的巨噬细胞、单核细胞和树突状细胞产生。IL-1β在 先天性和适应性免疫应答 中发挥核心作用,是 炎症反应的關鍵启动因子。
IL-1β通过结合 IL-1受体I型(IL-1RI) 发挥生物学效应,可诱导 多种促炎细胞因子和趋化因子 的产生、促进 T细胞活化、调控 细胞增殖与分化。IL-1β的异常表达与 多种炎症性疾病 密切相关,包括 类风湿性关节炎、动脉粥样硬化、2型糖尿病、阿尔茨海默病和自身炎症性疾病 等。靶向IL-1β的 生物制剂(如卡那单抗) 已在临床上用于治疗多种炎症性疾病。
Anti-IL1B/IL1F2 Polyclonal Antibody 是一种兔源多克隆抗体,可识别人、小鼠、大鼠的IL-1β蛋白,已广泛应用于ELISA、IHC、IF和WB检测,是炎症与免疫研究的 高质量工具抗体。

Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with IL1B/IL1F2 antibody (PHB95601) at 1 μg/ml.
1. Pulmonary Myeloid Cells in Mild Cases of COVID-19 Upregulate the Intracellular Fc Receptor TRIM21 and Transcribe Proteasome-Associated Molecules. PMID: 40141410
2. IL1B gene polymorphisms (rs1143627, rs16944) increase the risk of ANCA-associated vasculitis. PMID: 40253228
3. Secretory IgA binding to FCRL3 triggers shared inflammatory cytokine secretion by human regulatory T cells and effector T cells. PMID: 40313182
4. Systemic secukinumab treatment in patients with ankylosing spondylitis: the relationship between systemic and tear proinflammatory cytokines and ocular surface findings-a pilot study. PMID: 40394377
5. Sulfasalazine combined with anti-IL-1β mAb induces ferroptosis and immune modulation in oral squamous cell carcinoma. PMID: 40425823
6. Adipose-Derived Mesenchymal Stromal/Stem Cells Reduce Inflammatory Responses and Partially Alleviate Skin Symptoms in Imiquimod-Induced Psoriasis-Like Dermatitis Model Mice. PMID: 40500215
| Catalog No. | Product Name |
|---|---|
| PHB95601 | Anti-IL1B/IL1F2 Polyclonal Antibody |