抗TNF-α多克隆抗体 · 兔源 · 抗原亲和纯化
| 序号 | 您的研究方向 / 需求 | 本产品可直接应用 |
|---|---|---|
| 1 | 小鼠/大鼠TNF-α蛋白表达水平的定量检测 | 已验证ELISA应用，推荐稀释比1:20000 |
| 2 | 组织切片中TNF-α的定位与分布分析 | 已验证IHC应用，推荐稀释比1:100-1:300 |
| 3 | 细胞中TNF-α的免疫荧光定位 | 已验证IF应用，推荐稀释比1:100-1:300 |
| 4 | 细胞裂解液中TNF-α的蛋白免疫印迹检测 | 已验证WB应用，推荐稀释比1:500-1:2000 |
肿瘤坏死因子-α（Tumor Necrosis Factor-alpha, TNF-α） 是一种 多功能细胞因子，主要由活化的巨噬细胞、T细胞和自然杀伤细胞产生。TNF-α在 炎症反应、免疫调节、细胞凋亡和肿瘤抑制 等过程中发挥核心作用，是 先天性和适应性免疫应答 的关键介质。
TNF-α通过结合 TNFR1和TNFR2 两种受体发挥生物学效应，可诱导 促炎细胞因子 的产生、促进 免疫细胞活化、调控 细胞生存与死亡。TNF-α的异常表达与 多种疾病 密切相关，包括 类风湿性关节炎、炎症性肠病、银屑病、败血症和癌症 等。靶向TNF-α的 生物制剂（如阿达木单抗、英夫利西单抗） 已在临床上取得巨大成功。
Anti-TNFa/TNF-alpha Polyclonal Antibody 是一种兔源多克隆抗体，可识别小鼠和大鼠的TNF-α蛋白，已广泛应用于ELISA、IHC、IF和WB检测，是炎症与免疫研究的 高质量工具抗体。
Recombinant Protein lysates were subjected to SDS PAGE followed by western blot with TNFa/TNF-alpha antibody (PMB94401) at 1 μg/ml.
1. Effects of Rhodobacter sphaeroides protein on growth performance, nutrient digestibility, rumen fermentation, and serum metabolites in dairy calves during the pre- and postweaning periods. PMID: 40499903
2. Adipose-Derived Mesenchymal Stromal/Stem Cells Reduce Inflammatory Responses and Partially Alleviate Skin Symptoms in Imiquimod-Induced Psoriasis-Like Dermatitis Model Mice. PMID: 40500215
3. Combined TNF-α and OX40L targeting as a new treatment option for hidradenitis suppurativa. PMID: 40502542
4. Plasmapheresis for refractory toxic epidermal necrolysis unresponsive to conventional therapy: a case report and literature review. PMID: 40503234
5. TNFα signaling restores steady-state hematopoiesis in a TNFαKO mouse model of anemia of inflammation. PMID: 40512402
6. Structural insights into the activation and inhibition of the ADAM17-iRhom2 complex. PMID: 40512800
| Catalog No. | Product Name |
|---|---|
| PMB94401 | Anti-TNFa/TNF-alpha Polyclonal Antibody |
